Depress Anxiety:有氧运动联合舍曲林可减少重度抑郁症的焦虑症状

2021-04-29 MedSci原创 MedSci原创

重度抑郁症(MDD)是一种常见的精神障碍,在美国人口中的终生患病率为15-20%。焦虑症甚至更加普遍,并且通常与MDD同时发生。近日,研究人员进行了一项为期4个月的随机、安慰剂对照试验,探讨了运动和抗

重度抑郁症(MDD)是一种常见的精神障碍,在美国人口中的终生患病率为15-20%。焦虑症甚至更加普遍,并且通常与MDD同时发生。近日,研究人员进行了一项为期4个月的随机、安慰剂对照试验,探讨了运动和抗抑郁药物治疗在重度抑郁症(MDD)患者中的抗焦虑效果,并研究焦虑在治疗抑郁症状方面的潜在调节作用,研究结果已发表于Depress Anxiety。

研究纳入了148名患有MDD的久坐成人,随机分配到:(a) 监督下的锻炼,(b) 基于家庭的锻炼,(c) 舍曲林,或(d) 安慰剂对照。在治疗前和治疗后,用斯皮尔伯格焦虑量表测量状态焦虑的症状。使用汉密尔顿抑郁症评定量表(HAMD)和贝克抑郁症量表-II(BDI-II)评估抑郁症状。使用一般线性模型进行分析。

 

结果显示,与安慰剂对照组相比,运动组和舍曲林组在治疗后的状态焦虑评分较低(标准化差异=0.3 [95% CI = -0.6, -0.04]; p = 0.02)。与安慰剂对照组相比,在HAMD(p=0.004)和BDI-II(p=0.02)方面,治疗前较高的状态焦虑与较差的抑郁症结果有关。

综上所述,该研究结果表明,有氧运动以及舍曲林可减少MDD患者的焦虑症状。然而,较高的治疗前焦虑水平减弱了干预措施对抑郁症状的影响,特别是在锻炼者中。具有较高合并状态焦虑的MDD患者似乎不太可能从运动干预减少抑郁中受益,因此可能需要补充治疗,并特别关注焦虑。

 

原始出处:

 

James A Blumenthal, et al., The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial. Depress Anxiety. 2021 Feb;38(2):124-133. doi: 10.1002/da.23088. 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
    2021-11-22 ms6000000299174371

    学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
    2021-06-12 ms6000001624652641

    抑郁量表

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
    2021-04-29 明天jing

    有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
    2021-04-29 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1072692, encodeId=cb6210e269259, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70855721040, createdName=ms6000000299174371, createdTime=Mon Nov 22 08:00:22 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973059, encodeId=ad119e30593b, content=抑郁量表, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Sat Jun 12 15:39:37 CST 2021, time=2021-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923874, encodeId=7c5719238e4a3, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Wed Sep 01 14:38:53 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050420, encodeId=43b51050420e2, content=有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050559, encodeId=6654105055986, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Apr 29 13:38:53 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961473, encodeId=e9f99614e327, content=有氧运动如何客观定义呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 11:16:13 CST 2021, time=2021-04-29, status=1, ipAttribution=)]
    2021-04-29 ms6000001624652641

    有氧运动如何客观定义呢?

    0

相关资讯

Lancet Gastroenterol Hepatol:关注炎性肠病患者焦虑抑郁,改善预后

鼓励胃肠病专家筛查和治疗这些焦虑抑郁症状可能会改善IBD患者的预后。

反育儿焦虑:真实的你就是好妈妈

击破焦虑,母爱无须伟大。

Neurology:多发性硬化症妇女的围产期抑郁和焦虑现状分析

确诊为MS的妇女围产期抑郁的风险增加。在妊娠后5年内经历MS症状发作的妇女,在妊娠期间患抑郁症和焦虑症的风险增加。

Front. Cell Dev. Biol: 干预肠道微生物可治疗焦虑和抑郁

可以利用肠道微生物区系的干预治疗焦虑和抑郁,要么是通过合理使用抗生素,要么是通过鉴定影响大脑5-羟色胺、多巴胺和去甲肾上腺素能活动的新的微生物菌株。

Prostate Cancer P D:心理干预对前列腺癌抑郁、焦虑和苦恼的效果

前列腺癌的发病率越来越高,而死亡率越来越低,这将导致幸存者人数越来越多,健康状况负担会越来越重,因此,需要关注他们的心理健康。