Nat Commun:前列腺癌中雄激素受体结合位点高度变异

2020-02-21 AlexYang MedSci原创

雄激素受体(AR)信号几乎在所有类型的前列腺癌中都是必需的。AR介导转录的任何变化能够对致瘤过程和肿瘤生长起到深远的影响。虽然AR蛋白的变异已经有很多的研究,但是关于发生在AR结合DNA的非编码区的体细胞变异了解很少。最近,有研究人员使用临床全基因组测序发现了AR结合位点的变异比例存在大幅增加,并且比其他任何转录因子都要高,并且特异性的存在前列腺癌中。另外,研究人员还发现乳腺癌中雌激素受体结合位点

雄激素受体(AR)信号几乎在所有类型的前列腺癌中都是必需的。AR介导转录的任何变化能够对致瘤过程和肿瘤生长起到深远的影响。虽然AR蛋白的变异已经有很多的研究,但是关于发生在AR结合DNA的非编码区的体细胞变异了解很少。

最近,有研究人员使用临床全基因组测序发现了AR结合位点的变异比例存在大幅增加,并且比其他任何转录因子都要高,并且特异性的存在前列腺癌中。另外,研究人员还发现乳腺癌中雌激素受体结合位点的变异比例也提高,阐释了在谱系特异性转录因子上述情况也许是常见的。研究人员还表明了这些位于AR结合位点的变异以及其他相关的转录因子的变异是由于基础位点的错误修复引起的。

最后,研究人员指出,他们的工作阐释了非编码AR结合位点在前列腺癌中变异频率高,并能够影响增强子活性。

原始出处:

Tun? Morova, Daniel R. McNeill, Nada Lallous et al. Androgen receptor-binding sites are highly mutated in prostate cancer. Nat Commun. 11 Feb 2020

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    2020-04-25 liuli5079
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    2020-12-30 liye789132251
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    2020-02-21 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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