Br J Cancer:APC缺失通过介导Wnt/β-catenin/PKM2通路诱导结直肠癌细胞的Warburg效应

2020-10-24 xiaozeng MedSci原创

相比于正常细胞,癌细胞表现出新陈代谢的改变、有氧糖酵解的增加和氧化磷酸化的减少。与氧气供应无关的葡萄糖摄取和乳酸生成增加,被称为有氧糖酵解或Warburg效应,是大多数癌细胞的主要特征。这种重编程的新

相比于正常细胞,癌细胞表现出新陈代谢的改变、有氧糖酵解的增加和氧化磷酸化的减少。与氧气供应无关的葡萄糖摄取和乳酸生成增加,被称为有氧糖酵解或Warburg效应,是大多数癌细胞的主要特征。这种重编程的新陈代谢形式是癌细胞生长、增殖和存活所必需的,并促进了肿瘤的发生发展。

然而,在不同的肿瘤类型中,癌基因和肿瘤抑制基因控制肿瘤细胞代谢的机制并不同,且在大多数情况下,引起代谢酶表达改变的相关分子机制还知之甚少。此外,尽管细胞代谢重编程被认为是肿瘤发生发展过程中的关键事件,但启动和控制该重编程作用的调控机制和信号转导通仍然未知。

KYA1797K抑制代谢酶的表达

Wnt/β-catenin信号通路是调节重要生物学过程(包括正常发育和肿瘤发生)的主要通路。该研究揭示了Warburg效应与异常激活的Wnt/β-catenin信号转导通路之间的关键联系,特别是在APC(腺瘤性结肠息肉病相关基因)功能缺失性的结直肠癌(CRC)中。

在CRC中PKM2和LDHA的表达水平与Wnt/catenin信号正相关

研究人员通过蛋白质组学分析,评估Wnt/β-catenin信号抑制剂KYA1797K对CRC中细胞蛋白的整体作用。结果显示,PKM2和LDHA被确定为受Wnt/β-catenin信号调节的关键分子。进一步研究发现,APC缺失会导致包括PKM2和LDHA在内的代谢基因的表达水平升高,以及葡萄糖消耗和乳酸分泌的增加。

PKM2对Warburg效应和肿瘤发生的作用

通过在Apcmin/+小鼠模型和CRC患者的肿瘤组织中分析了Wnt/β-catenin信号激活与肿瘤代谢之间的关系。并评估移植瘤模型中PKM2对肿瘤代谢的作用。研究人员发现在小鼠模型和肿瘤组织中糖酵解基因与Wnt靶基因的表达水平升高。研究人员发现,敲除PKM2会抑制Warburg效应和APC突变CRC细胞诱导的移植瘤的生长。


综上,该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应。


原始出处:

Cha, P., Hwang, J., Kwak, D. et al. APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer. Br J Cancer (19 October 2020).

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (13)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2021-01-24 147f71a9m80暂无昵称

    哈哈哈哈哈哈哈

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2020-10-26 Nebula-Qin

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2020-10-25 yxch36
  6. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2020-10-25 by2009
  8. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2020-10-25 zhwj
  10. [GetPortalCommentsPageByObjectIdResponse(id=1805762, encodeId=f4551805e6226, content=<a href='/topic/show?id=95e7e87031b' target=_blank style='color:#2F92EE;'>#结直肠癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78703, encryptionId=95e7e87031b, topicName=结直肠癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Thu Aug 26 08:50:49 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652678, encodeId=de1216526e879, content=<a href='/topic/show?id=a68d1860863' target=_blank style='color:#2F92EE;'>#Warburg效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18608, encryptionId=a68d1860863, topicName=Warburg效应)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=301324326936, createdName=snf701215, createdTime=Sun Aug 08 16:50:49 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919380, encodeId=2eeb9193807f, content=哈哈哈哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29d25258008, createdName=147f71a9m80暂无昵称, createdTime=Sun Jan 24 08:24:38 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894599, encodeId=ded989459908, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Oct 26 19:27:16 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252740, encodeId=e1221252e40d8, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370396, encodeId=ea0213e039632, content=<a href='/topic/show?id=f75726283f' target=_blank style='color:#2F92EE;'>#APC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2628, encryptionId=f75726283f, topicName=APC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372301, encodeId=d62a13e230189, content=<a href='/topic/show?id=4e131432eda' target=_blank style='color:#2F92EE;'>#PKM2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14327, encryptionId=4e131432eda, topicName=PKM2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453433, encodeId=c2991453433b1, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598677, encodeId=05a515986e75f, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Sun Oct 25 15:50:49 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894079, encodeId=cee58940e992, content=该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 24 10:08:21 CST 2020, time=2020-10-24, status=1, ipAttribution=)]
    2020-10-24 神盾医疗局局长Jack

    该研究结果揭示,APC缺失诱导的β-catenin/PKM2调节通路激活了CRC中的Warburg效应

    0

相关资讯

JAMA Oncol:多喝咖啡还能减少结直肠癌死亡,延长生存期

通过对大型临床试验数据的进一步分析,发现对于晚期和转移性结直肠癌患者,每天喝2-3杯咖啡的患者总体生存期更长,癌症恶化风险更低,每天喝4杯咖啡的患者收益更大。

Cell Death Dis:LncRNA LINC01106通过介导正反馈回路促进结直肠癌的发生发展

据统计,全球每年约有60万例结直肠癌(CRC)死亡病例,在所有癌症中位居第三。由于抗肿瘤疗法的改进,近几十年来每年的死亡人数正在逐渐减少。既往研究显示,遗传学和表观遗传学的改变与CRC的恶化密切相关。

JAMA Oncol :咖啡又一功效!可改善结直肠癌晚期或转移性患者的生存率和恶化风险

结直肠癌(CRC)是世界第三高发恶性肿瘤,近十年来在我国的发病率逐年上升。大量的CRC患者最终会发展成转移性疾病,姑息性治疗的5年生存率仅为14%。

Brit J Cancer:抗生素使用与结直肠癌风险的关系

抗生素使用与CRC风险之间的相关性在广谱和窄谱抗生素之间似乎有所不同。尚不清楚这种关联是否具有因果关系,需要更多的机制研究进一步阐明药物与微生物组之间的相互作用。

Stem Cell Reports:男性更易患结直肠癌,这与雄性激素水平有关

据世界卫生组织(WHO)最新统计,结直肠癌是全球范围内发病率排名第三、致死率排名第二的癌种。结直肠癌可能发生在任何年龄,但大多只影响老年人,它通常开始于结肠内部形成的称为息肉的小而良性的细胞团。

Br J Cancer:长期使用广谱抗生素增加结直肠癌患病风险

结直肠癌(CRC)作为全球范围内第四大最常见的疾病死亡原因,占癌症相关死亡的百分之十。尽管在一些高收入国家中该病的发病率正在逐年下降,然而几大洲中