Korean J Gastroenterol:β-茶碱可抑制幽门螺杆菌的感染

2020-09-26 MedSci原创 MedSci原创

幽门螺杆菌(H.pylori)感染在韩国很常见,会引起各种胃肠道症状。最近的报告显示,幽门螺杆菌的根除率有所下降。β-茶碱是一种天然的双环芝麻素,存在于丁香、罗勒和肉桂等多种植物物种中,据报

幽门螺杆菌(H.pylori)感染在韩国很常见,会引起各种胃肠道症状。最近的报告显示,幽门螺杆菌的根除率有所下降。β-茶碱是一种天然的双环芝麻素,存在于丁香、罗勒和肉桂等多种植物物种中,据报道β-茶碱具有抗炎和抗菌作用。本研究探讨了β-茶碱对幽门螺杆菌的抑制作用及其作为胃肠道替代药物的潜在作用,其研究结果已在线发表于Korean J Gastroenterol。

这项为期8周的随机双盲、安慰剂对照试验将受试者分为β-茶碱组(33名患者接受126mg/天的β-茶碱)和安慰剂组(33名患者接受安慰剂制剂)。使用内镜和尿素呼气试验(UBT)评价两组患者在用药前后幽门螺杆菌浸润的炎症水平和根除率。给药前后对比两组患者的血清细胞因子水平(肿瘤坏死因子-α,白细胞介素[IL]-1β和IL-6)。

 

结果显示,两组均未观察到幽门螺杆菌的完全根除。此外,UBT和更新的Sydney评分没有明显变化。另一方面,β-茶碱组在恶心(p=0.025)和上腹痛(p=0.018)方面有显著改善,同时血清IL-1β水平也有所下降(p=0.038)。

综上所述,该研究结果表明,β-茶碱能改善患者的消化不良症状,可作为胃肠道疾病的有效辅助治疗手段。

 

原始出处:

 

Hyun Ik ShimDong Jin Song, et al., Inhibitory Effects of β-caryophyllene on Helicobacter pylori Infection: A Randomized Double-blind, Placebo-controlled Study. Korean J Gastroenterol. 2019 Oct 25;74(4):199-204. doi: 10.4166/kjg.2019.74.4.199.

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    2021-06-14 kcb069
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    2021-06-04 许安
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    2020-09-28 hbwxf

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