AP&T:咖啡喝的越多,肝脏相关死亡率就越低!

2020-09-10 MedSci原创 MedSci原创

世界范围内,肝硬化每年导致超过100万人死亡,占所有死亡人数的2%以上,此外,由于肝硬化引起的肝细胞癌(HCC)是全球第三大最常见的癌症。

        世界范围内,肝硬化每年导致超过100万人死亡,占所有死亡人数的2%以上,此外,由于肝硬化引起的肝细胞癌(HCC)是全球第三大最常见的癌症,每年造成745 000人死亡。几十年来,人们已经认识到咖啡的摄入可以一定程度地预防肝脏疾病的发生,在最近几年,已经出现了越来越多的研究认为,加大咖啡的摄入量,不仅可以改善肝脏生化指标,也减缓发展为肝硬化的速度。

         

 

        在迄今为止最大的一项高质量前瞻性队列研究中,Setiawan及其同事发现每天喝2到3杯/天的人,肝硬化死亡减少了46%;在调整了主要混杂因素(包括年龄,BMI,糖尿病,性别,种族,受教育程度和饮酒量)后,每天喝4杯或更多杯的人的肝硬化死亡减少了71%。这样欣喜的数据让这个学界为之鼓舞,那么本项研究也从咖啡剂量的角度探究了咖啡与肝脏疾病死亡率之间的关系。

 

        研究人员使用2016年全球疾病负担数据集中年龄大于15岁的患者的生活数据进行数据分析,对每日2杯以上咖啡的患者均进行了分析,人并对均咖啡摄入量增加对肝脏相关死亡率的影响进行了建模,最后对咖啡剂量的影响进行了相对应调整。

 

         研究结果显示:2016年,全球估计有1240201人是因为肝脏相关疾病死亡的。2016年,全球肝脏相关死亡率中位数为15例死亡/ 100000人口/年( IQR:每10万人中有11-21例死亡)。如果所有人均咖啡摄入量≤2杯/天的国家增加到> 2杯/天,那么2016年与肝有关的死亡总数预计将为630947人,将会有452861 人避免了死亡(PPR: 7.8肝相关死亡/ 100000 /年)。如果人均日消费量≥4杯/天,那么2016年与肝脏相关的死亡人数预计为360523(95%CI 359825-361 992),其中723287人将会避免死亡(PPR: 12.1肝相关死亡/ 100000 /年)。

 

        最后研究人员说道:本项研究已经证实咖啡对肝脏相关死亡率的影响,那么按人口数量计算,人均咖啡消费量增加到每天2杯以上,每年就有可能避免成千上万与肝脏相关的死亡。

 

 

原始出处:

Paul Gow. Et al. Estimates of the global reduction in liver disease‐related mortality with increased coffee consumption: an analysis of the Global Burden of Disease Dataset. Alimentary Pharmacology and Therapeutics.2020.

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    2020-09-11 124902dfm95暂无昵称

    这里的咖啡☕️是清咖吗?

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=884522, encodeId=9f0488452278, content=这里的咖啡☕️是清咖吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/05/9151d1e89e73add788e7d96c55fb5dec.jpg, createdBy=dcfd2497546, createdName=124902dfm95暂无昵称, createdTime=Fri Sep 11 12:37:37 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884441, encodeId=351b88444152, content=咖啡引起熬夜,熬夜也伤肝, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/4c573fa4d4584e158c9c5d8c8c12eb17/164193dac022418d9259695640b4e1bd.jpg, createdBy=a0ec2056748, createdName=1571ecfcf9m, createdTime=Fri Sep 11 08:58:51 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884347, encodeId=e10788434e11, content=不过喝<a href='/topic/show?id=f2b0103890dd' target=_blank style='color:#2F92EE;'>#两杯咖啡#</a>可以改善<a href='/topic/show?id=2ddd1038913c' target=_blank style='color:#2F92EE;'>#肝脏生化指标#</a>,我还是很开心的。喜欢喝咖啡~, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103890, encryptionId=f2b0103890dd, topicName=两杯咖啡), TopicDto(id=103891, encryptionId=2ddd1038913c, topicName=肝脏生化指标)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:03:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884344, encodeId=f55a884344a8, content=虽然我很喜欢喝咖啡,特别是拿铁和澳白,但是我还是认为喝<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>还是要适量吧,喝多了晚上会睡不着,熬夜伤肝~。题目不能说咖啡喝的越多,肝脏相关死亡率就越低!, beContent=null, objectType=article, channel=null, level=null, likeNumber=270, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:01:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884265, encodeId=353288426589, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>,减少<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>以及<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>的风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=81302, encryptionId=cb65813029a, topicName=肝硬化), TopicDto(id=81269, encryptionId=370d8126914, topicName=肝癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:08:36 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-11 1571ecfcf9m

    咖啡引起熬夜,熬夜也伤肝

    0

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    2020-09-10 Jessica

    不过喝#两杯咖啡#可以改善#肝脏生化指标#,我还是很开心的。喜欢喝咖啡~

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=884522, encodeId=9f0488452278, content=这里的咖啡☕️是清咖吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/05/9151d1e89e73add788e7d96c55fb5dec.jpg, createdBy=dcfd2497546, createdName=124902dfm95暂无昵称, createdTime=Fri Sep 11 12:37:37 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884441, encodeId=351b88444152, content=咖啡引起熬夜,熬夜也伤肝, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/4c573fa4d4584e158c9c5d8c8c12eb17/164193dac022418d9259695640b4e1bd.jpg, createdBy=a0ec2056748, createdName=1571ecfcf9m, createdTime=Fri Sep 11 08:58:51 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884347, encodeId=e10788434e11, content=不过喝<a href='/topic/show?id=f2b0103890dd' target=_blank style='color:#2F92EE;'>#两杯咖啡#</a>可以改善<a href='/topic/show?id=2ddd1038913c' target=_blank style='color:#2F92EE;'>#肝脏生化指标#</a>,我还是很开心的。喜欢喝咖啡~, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103890, encryptionId=f2b0103890dd, topicName=两杯咖啡), TopicDto(id=103891, encryptionId=2ddd1038913c, topicName=肝脏生化指标)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:03:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884344, encodeId=f55a884344a8, content=虽然我很喜欢喝咖啡,特别是拿铁和澳白,但是我还是认为喝<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>还是要适量吧,喝多了晚上会睡不着,熬夜伤肝~。题目不能说咖啡喝的越多,肝脏相关死亡率就越低!, beContent=null, objectType=article, channel=null, level=null, likeNumber=270, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:01:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884265, encodeId=353288426589, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>,减少<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>以及<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>的风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=81302, encryptionId=cb65813029a, topicName=肝硬化), TopicDto(id=81269, encryptionId=370d8126914, topicName=肝癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:08:36 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 Jessica

    虽然我很喜欢喝咖啡,特别是拿铁和澳白,但是我还是认为喝#咖啡#还是要适量吧,喝多了晚上会睡不着,熬夜伤肝~。题目不能说咖啡喝的越多,肝脏相关死亡率就越低!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=884522, encodeId=9f0488452278, content=这里的咖啡☕️是清咖吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/05/9151d1e89e73add788e7d96c55fb5dec.jpg, createdBy=dcfd2497546, createdName=124902dfm95暂无昵称, createdTime=Fri Sep 11 12:37:37 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884441, encodeId=351b88444152, content=咖啡引起熬夜,熬夜也伤肝, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/4c573fa4d4584e158c9c5d8c8c12eb17/164193dac022418d9259695640b4e1bd.jpg, createdBy=a0ec2056748, createdName=1571ecfcf9m, createdTime=Fri Sep 11 08:58:51 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884347, encodeId=e10788434e11, content=不过喝<a href='/topic/show?id=f2b0103890dd' target=_blank style='color:#2F92EE;'>#两杯咖啡#</a>可以改善<a href='/topic/show?id=2ddd1038913c' target=_blank style='color:#2F92EE;'>#肝脏生化指标#</a>,我还是很开心的。喜欢喝咖啡~, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103890, encryptionId=f2b0103890dd, topicName=两杯咖啡), TopicDto(id=103891, encryptionId=2ddd1038913c, topicName=肝脏生化指标)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:03:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884344, encodeId=f55a884344a8, content=虽然我很喜欢喝咖啡,特别是拿铁和澳白,但是我还是认为喝<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>还是要适量吧,喝多了晚上会睡不着,熬夜伤肝~。题目不能说咖啡喝的越多,肝脏相关死亡率就越低!, beContent=null, objectType=article, channel=null, level=null, likeNumber=270, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 22:01:59 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884265, encodeId=353288426589, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>,减少<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>以及<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>的风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=81302, encryptionId=cb65813029a, topicName=肝硬化), TopicDto(id=81269, encryptionId=370d8126914, topicName=肝癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:08:36 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 lovetcm

    #咖啡#,减少#肝硬化#以及#肝癌#的风险

    0

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