Brit J Cancer:微波消融治疗非小细胞肺癌患者根治术后肺部寡复发的效果

2021-06-16 MedSci原创 MedSci原创

对于接受根治性手术切除后肺部寡复发的NSCLC患者,MWA应被认为是一种有效且安全的治疗手段。

微波消融(MWA)是一种有效的微创治疗肺癌的手段。近日,肿瘤学领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员旨在评估MWA对非小细胞肺癌根治术后肺寡复发中的作用。

从2012年6月至2020年1月期间,研究人员回顾性地分析了103例既往接受根治性手术切除后肺部寡复发的NSCLC患者。该研究的主要终点为术后无进展生存期(PFS)。次要终点为术后总生存期(OS)、失败的类型、并发症和与预后相关的预测因素。

在103例确诊患者中,135例肺部寡复发发生的中位间隔为34.8个月。该研究共进行143次MWA,以消融所有的结节。受试者的中位PFS和OS分别为15.1个月和40.6个月。

典型病例影像学结果

MWA术后,15例(14.6%)患者以局部复发为第一事件,45例(43.7%)患者出现胸腔内寡复发,20例(19.4%)患者出现了远处转移。在多因素分析中,局部复发和胸腔内寡复发不是OS的显著预测因素(分别有P=0.23和0.26)。然而,远处转移可以预测OS (HR=5.37,95%CI为1.04-27.8,P=0.04)。

由此可见,对于接受根治性手术切除后肺部寡复发的NSCLC患者,MWA应被认为是一种有效且安全的治疗手段

原始出处:

Yang Ni.et al.Multicentre study of microwave ablation for pulmonary oligorecurrence after radical resection of non-small-cell lung cancer.Brit J Cancer.2021.https://www.nature.com/articles/s41416-021-01404-y

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    2021-09-16 沈敏

    对于接受根治性手术切除后肺部寡复发的NSCLC患者,MWA应被认为是一种有效且安全的治疗手段。

    0

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    2021-09-12 ms3000000161626604

    微波消融(MWA)是一种有效的微创治疗肺癌的手段。

    0

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    2021-06-17 jeanqiuqiu
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    2021-06-16 yde2801fm***3926(暂无匿称)

    学习了

    0

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NEJM:Sotorasib治疗KRASp.G12C突变晚期非小细胞肺癌II期临床数据喜人

Sotorasib在先前接受过铂化疗或免疫治疗的KRASp.G12C突变非小细胞肺癌患者中表现出良好的治疗效果且安全性良好