J Periodontol:透明质酸对种植体周围炎的龈下微生物群的短期影响

2020-12-18 MedSci原创 MedSci原创

截止目前,种植体周围的尚无有效的治疗方法。近日,一项随机对照试验评估了透明质酸(HA)凝胶处理45天时对种植体周围炎微生物组的影响,研究结果已在线发表于J Periodontol。

截止目前,种植体周围的尚无有效的治疗方法。近日,一项随机对照试验评估了透明质酸(HA)凝胶处理45天时对种植体周围炎微生物组的影响,研究结果已在线发表于J Periodontol。

研究纳入了54名种植体周围炎患者,包含了108种植体。在基线和治疗45天后收集种植体周围炎植体周围的拭子。采用16S rRNA测序技术研究HA凝胶对龈下微生物组的影响。

 

结果,基线时样本中获得了三个具有不同微生物组成的分层,代表了与种植体周围炎相关的三个主要微生物菌群。第1层用HA治疗后,所有微生物组都没有显示出差异,而在第2层,链球菌、Veillonella、Rothia和Granulicatella的水平减少(P <0.05)。同样,HA处理后,第三层的普雷沃特氏菌和弯曲菌的水平也减少(P < 0.05)。与对照组相比,HA处理后,第3层的微生物多样性减少(P < 0.05),而对照组则增加(P < 0.05)。

综上所述,该研究结果表明,HA降低了与种植体周围炎相关的微生物的相对丰度,尤其是早期的定植菌,表明在疾病发展的最初阶段有特殊作用。HA没有改变非口腔属的相对丰度。在种植体周围炎的晚期阶段使用HA会减少微生物α多样性,表明其可对抗种植体周围细菌的繁殖。

 

原始出处:

 

Ana Soriano-LermaAntonio Magán-Fernández, et al., Short-term effects of hyaluronic acid on the subgingival microbiome in peri-implantitis: A randomized controlled clinical trial. J Periodontol. 2020 Jun;91(6):734-745. doi: 10.1002/JPER.19-0184. 

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    2021-08-27 huangdf
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level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74789, encryptionId=f16de47893f, topicName=种植体周围炎), TopicDto(id=94824, encryptionId=d394948247b, topicName=透明质酸/胶原水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Dec 23 20:41:35 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276737, encodeId=277112e673770, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Dec 19 14:56:07 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344000, 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topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Sat Dec 19 14:56:07 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909064, encodeId=b31c909064ba, content=透明质酸真的是个好东西啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8KImyUciaABc4HEhaES8kr9TAFRn4icuU3of5jGnqyNXjIJLO3xKicUcz6qltVeuCRf2ZsMzRtCgoA/132, createdBy=b6325257545, createdName=Ershat, createdTime=Fri Dec 18 09:51:50 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909029, encodeId=692890902960, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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  8. 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topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Sat Dec 19 14:56:07 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909064, encodeId=b31c909064ba, content=透明质酸真的是个好东西啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8KImyUciaABc4HEhaES8kr9TAFRn4icuU3of5jGnqyNXjIJLO3xKicUcz6qltVeuCRf2ZsMzRtCgoA/132, createdBy=b6325257545, createdName=Ershat, createdTime=Fri Dec 18 09:51:50 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909029, encodeId=692890902960, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Fri Dec 18 07:33:37 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909022, encodeId=fb9e90902281, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201211/3bb57304272c4b2b86735fa78a30e9bf/99e093a7c19f492aa0811287a9a91807.jpg, createdBy=a0701982805, createdName=慎独, createdTime=Fri Dec 18 07:21:59 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-18 Ershat

    透明质酸真的是个好东西啊

    0

  9. 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topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Sat Dec 19 14:56:07 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909064, encodeId=b31c909064ba, content=透明质酸真的是个好东西啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8KImyUciaABc4HEhaES8kr9TAFRn4icuU3of5jGnqyNXjIJLO3xKicUcz6qltVeuCRf2ZsMzRtCgoA/132, createdBy=b6325257545, createdName=Ershat, createdTime=Fri Dec 18 09:51:50 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909029, encodeId=692890902960, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Fri Dec 18 07:33:37 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909022, encodeId=fb9e90902281, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201211/3bb57304272c4b2b86735fa78a30e9bf/99e093a7c19f492aa0811287a9a91807.jpg, createdBy=a0701982805, createdName=慎独, createdTime=Fri Dec 18 07:21:59 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-18 Lizhihua6

    学习了

    0

  10. 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