Translational Psychiatry:血液IL-6、GDNF和BDNF可能是与情绪障碍、物质滥用障碍和自杀相关的外周生物标志物

2021-06-05 MedSci原创 MedSci原创

血液IL-6、GDNF和BDNF可能是与情绪障碍、物质障碍和自杀相关的脑生物学信息丰富的外周生物标志物。

理解情绪和物质使用障碍的病理生理学将涉及整合多个生物学途径。炎症/白介素和细胞生长/神经营养因子细胞功能通路这两个领域的研究越来越受到关注。神经营养因子参与了成人脑内细胞增殖、迁移、分化、神经元存活以及神经元功能和结构的维护。脑源性神经营养因子(BDNF)和胶质细胞系源性神经营养因子(GDNF)是重要的脑信号蛋白,其在关键神经通路中的缺失与精神疾病的发生有关。BDNF和GDNF也被假定在酒精依赖、戒断调节方面有作用。 有严重抑郁症和自杀行为的患者外周白介素和神经营养因子水平发生了改变,但目前尚不清楚中枢神经系统是否也发生了类似的异常。 Bharathi S. Gadad等比较了正常对照、情绪障碍组、情绪障碍合并AUD/SUD(酒精滥用障碍、物质滥用障碍)、AUD/SUD无情绪障碍组的IL-6, IL-1β, BDNF和GDNF在尸检血浆和脑脊液中的差异。该研究发表在Translational Psychiatry杂志。 为了解决这些问题,Bharathi S. Gadad等从情绪障碍、情绪障碍合并AUD/SUD、AUD/SUD和正常对照的个体中收集了尸检血浆(n = 29)、脑脊液(n

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    2021-10-16 zchen
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createdBy=8ba828506031, createdName=ms1065684921169360, createdTime=Thu Feb 03 04:12:30 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796055, encodeId=1b071e960558f, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Mon Nov 01 04:12:30 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841693, encodeId=e64d184169316, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, 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style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Jun 15 09:12:30 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795932, encodeId=f0281e959324b, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423850, encodeId=718f1423850cb, content=<a href='/topic/show?id=ec6d3299f3' target=_blank style='color:#2F92EE;'>#BDNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3299, encryptionId=ec6d3299f3, topicName=BDNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10ba3855050, createdName=apoenzyme, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1701606, encodeId=01df1e0160692, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Sat Oct 16 02:12:30 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688246, encodeId=ee5d16882461d, content=<a href='/topic/show?id=5d5553155d7' target=_blank style='color:#2F92EE;'>#情绪障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53155, encryptionId=5d5553155d7, topicName=情绪障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ba828506031, createdName=ms1065684921169360, createdTime=Thu Feb 03 04:12:30 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796055, encodeId=1b071e960558f, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Mon Nov 01 04:12:30 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841693, encodeId=e64d184169316, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Oct 07 21:12:30 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792258, encodeId=08091e922586b, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Aug 28 10:12:30 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657498, encodeId=b8a8165e498ef, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Jun 15 09:12:30 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795932, encodeId=f0281e959324b, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423850, encodeId=718f1423850cb, content=<a href='/topic/show?id=ec6d3299f3' target=_blank style='color:#2F92EE;'>#BDNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3299, encryptionId=ec6d3299f3, topicName=BDNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10ba3855050, createdName=apoenzyme, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1701606, encodeId=01df1e0160692, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Sat Oct 16 02:12:30 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688246, encodeId=ee5d16882461d, content=<a href='/topic/show?id=5d5553155d7' target=_blank style='color:#2F92EE;'>#情绪障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53155, encryptionId=5d5553155d7, topicName=情绪障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ba828506031, createdName=ms1065684921169360, createdTime=Thu Feb 03 04:12:30 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796055, encodeId=1b071e960558f, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Mon Nov 01 04:12:30 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841693, encodeId=e64d184169316, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, 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style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Jun 15 09:12:30 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795932, encodeId=f0281e959324b, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Sun Feb 06 00:12:30 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067572, encodeId=d81b206e572db, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Sep 21 19:12:30 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273807, encodeId=693d12e38079c, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423850, encodeId=718f1423850cb, content=<a href='/topic/show?id=ec6d3299f3' target=_blank style='color:#2F92EE;'>#BDNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3299, encryptionId=ec6d3299f3, topicName=BDNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10ba3855050, createdName=apoenzyme, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=)]
    2021-06-15 bsmagic9140
  7. 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423850, encodeId=718f1423850cb, content=<a href='/topic/show?id=ec6d3299f3' target=_blank style='color:#2F92EE;'>#BDNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3299, encryptionId=ec6d3299f3, topicName=BDNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10ba3855050, createdName=apoenzyme, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1701606, encodeId=01df1e0160692, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Sat Oct 16 02:12:30 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688246, encodeId=ee5d16882461d, content=<a href='/topic/show?id=5d5553155d7' target=_blank style='color:#2F92EE;'>#情绪障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53155, encryptionId=5d5553155d7, topicName=情绪障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  9. 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style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Jun 15 09:12:30 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795932, encodeId=f0281e959324b, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423850, encodeId=718f1423850cb, content=<a href='/topic/show?id=ec6d3299f3' target=_blank style='color:#2F92EE;'>#BDNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3299, encryptionId=ec6d3299f3, topicName=BDNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10ba3855050, createdName=apoenzyme, createdTime=Mon Jun 07 14:12:30 CST 2021, time=2021-06-07, status=1, ipAttribution=)]
    2021-06-07 kzlchina
  10. 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    2021-06-07 apoenzyme

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白介素6 [IL-6]或其受体目前是炎症性肠病[IBD]靶向生物治疗的候选目标。

Lancet Rheumato: 重症新冠肺炎:白介素抑制可用,但不能都用!

如何用白介素抑制剂治疗重度新冠肺炎患者?

Lancet:Ziltivekimab可有效降低高动脉粥样硬化风险个体的炎症标志物

采用Ziltivekimab抑制IL-6明显减少了与动脉粥样硬化相关的炎症和血栓形成的生物标志物

Cell Death Dis:肿瘤相关成纤维细胞可影响结肠癌细胞的生理节律

生物钟可以调节蛋白质的表达水平及其功能特性,如细胞生长相关的节律,而这些作用能够调节细胞稳态和组织的整体活性。

ATVB:IL-6是传统危险因素与心肌梗死之间关联的介导因素

血浆IL-6和IL-6二元复合物浓度与未来心肌梗死显著相关。该研究的数据表明血浆IL-6和IL-6二元复合物的浓度升高均可以部分解释这一关联,其可能与吸烟者和高血压参与者MI发生风险增加有关。