Allergy Asthma Clin Immunol:治疗树花粉引起的季节性过敏性鼻炎的成本最小化选择:舌下免疫治疗药片

2021-07-27 AlexYang MedSci原创

近期,有研究人员进行了成本最小化分析(CMA),评估了在加拿大(安大略省和魁北克省)引入SQ树舌下免疫疗法(SLIT)药片的经济情况,该片剂以ITULATEK®上市(2020年4月获得加拿大卫

近期,有研究人员进行了成本最小化分析(CMA),评估了在加拿大(安大略省和魁北克省)引入SQ树舌下免疫疗法(SLIT)药片的经济情况,该片剂以ITULATEK®上市(2020年4月获得加拿大卫生部监管批准),用于治疗花粉(桦树、桤木和/或榛树)引起的季节性过敏性鼻炎,在加拿大,树花粉皮下免疫疗法(SCIT)已经是一种可用的治疗选择。

本研究的CMA是基于这样的假设:SQ树皮下免疫治疗片的疗效与树花粉SCIT相当。模型中采用了社会视角,包含了相关的药物成本、医疗服务成本和生产力损失。模型中的时间跨度为三年,相当于过敏免疫疗法的最短治疗疗程。资源使用和成本基于现有的公开资料,并由安大略省和魁北克省执业的加拿大专业临床医生(过敏症专家)验证。根据加拿大卫生药品和技术管理局(CADTH)的指导方针,采用了1.5%的贴现率。为了评估结果的稳健性,研究人员还进行了情景分析,对选定的参数(如树花粉SCIT资源使用、贴现率、注射次数、每年SCIT剂量以及护士时间支持)进行了测试,来评估它们对分析结果的影响。

研究结果发现,在安大略省和魁北克省,三年治疗的直接成本,包括药物成本和医生服务成本,在SQ树SLIT-片剂和树花粉SCIT中是相似的(分别为2799.01美元和2838.70美元,2233.76美元和2266.05美元)。然而,当间接成本(包括病人的出行费用和损失的工作时间)包括在模型中时,安大略省和魁北克省使用SQ树SLIT-片剂治疗的总节省额分别为1111.79美元和1199.87美元。情景分析结果显示,假设的条件变化使得SQ树SLIT-片剂比树花粉SCIT更加节省成本。

3年SQ树SLIT药片治疗与树花粉SCIT治疗的花费和潜在的节省情况

综上所述,CMA表明,从安大略省和魁北克省的社会角度考虑来看,SQ树SLIT-片剂是替代树花粉SCIT的一种成本最小的疗法

原始出处:

Anne K Ellis, Rémi Gagnon, Eva Hammerby et al. Sublingual immunotherapy tablet: a cost-minimizing alternative in the treatment of tree pollen-induced seasonal allergic rhinitis in Canada. Allergy Asthma Clin Immunol. Jul 2021

 

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    2022-03-10 skhzy
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    2021-07-29 膀胱癌
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    2021-07-29 30397606
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