Br J Cancer:计算机断层扫描(CT)相比于胸透(CXR)在妊娠滋养细胞瘤形成的初步评估中并无优势

2020-12-29 xiaozeng MedSci原创

妊娠滋养细胞肿瘤(GTN)通常采用国际妇产科联合会(FIGO)评分系统进行分类,以鉴定患者属于单药化疗耐药(SACR)的低风险(得分≤6)或高风险(得分≥7)。

妊娠滋养细胞肿瘤(GTN)通常采用国际妇产科联合会(FIGO)评分系统进行分类,以鉴定患者属于单药化疗耐药(SACR)的低风险(得分≤6)或高风险(得分≥7)。

FIGO评分系统通常使用胸部X光片(CXR)方式作为评估肿瘤肺转移的标准。计算机断层扫描(CT)在检测肺转移方面相比于胸部X光片(CXR)检测具有更高的敏感性,但目前尚不清楚其对患者结局的影响。

箱形图比较基于CXR和CT的肺转移成像的FIGO得分

在该研究中,共有589名进行GTN评估的患者同时接受了CXR和CT检查。患者的治疗决策主要基于CXR。研究人员比较了CXR和CT检测的患者的转移次数、风险评分和风险类别。相比于患者的预后情况、SACR的发生率、TNhCG(正常绒毛膜促性腺激素)达到正常的时间和原发化疗耐药性(PCR),CT相关的胸部评分被评估为影响治疗决策的主要因素。

相关治疗结果流程图

该研究结果显示,相比于CXR,CT的转移检测和FIGO评分更高。 在188例(31.9%)患者中CT检测的FIGO评分更高,其中的43例从低风险被重新分类为高风险,而其中的23例患者(53.5%)接受了治愈性单药化疗。当评分或风险组改变时,SACR发生率更高。 CXR检测的转移而非CT检测的能够延长TNhCG时间。逻辑回归分析显示,在预测PCR时,CXR与CT之间没有差异。


综上,该研究结果显示,CT能够将改善患者的SACR预测,但并不影响总体的治疗结果、TNhCG或PCR的预测。而由于较低的辐射剂量以及成本的问题,研究人员建议继续使用基于CXR的评估策略。


原始出处:

Parker, V.L., Winter, M.C., Whitby, E. et al. Computed tomography chest imaging offers no advantage over chest X-ray in the initial assessment of gestational trophoblastic neoplasia. Br J Cancer (16 December 2020).

 

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    2021-04-14 bioon14
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    2020-12-30 124764c3m24(暂无昵称)

    这个新

    0

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    2020-12-29 phoebeyan520

    很好的文章,认真学习

    0

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    2020-12-29 慎独

    学习学习了

    0

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