Cardiovasc Diabetol:血清铁水平越高,2型糖尿病风险越高!

2022-02-24 Nebula MedSci原创

血清铁蛋白水平与2型糖尿病的发病风险呈独立地正相关。

既往研究已报道,铁储备(估计为铁蛋白水平)与 2 型糖尿病 (T2D) 相关,但铁储备与冠心病 (CHD) 和脑血管疾病 (CEVD) 的相关性仍无定论。目前尚无研究集中在同一人群中同时评估铁储备与上述心血管代谢疾病(CMD)之前的关联。

本研究旨在评估苏格拉人群血清铁与2型糖尿病、冠心病和脑血管疾病风险的相关性。

这是一项在参与1995年和1998年苏格兰健康调查的6497位参与者中开展的纵向研究,这些参与者被随访至2011年。采用Cox回归模型进行分析,并根据年龄、性别/绝经状态、纤维蛋白原、GGT 水平、吸烟、饮酒、总胆固醇、HDL-胆固醇、血压和体重指数(BMI)进行调整。

血清铁水平与T2DM患病风险的相关性

在随访过程中,4.9%的参与者患上了T2D,5.3%的参与者患上了CHD,2.3%的参与者患上了CEVD。根据铁蛋白水平将参与者分成四组,血清铁蛋白水平与T2D、CHD和CEVD患病风险呈正相关,但在调整协变量后仅与T2D患病风险相关(Q4 vs Q1:校正风险比[HR] 1.59,p=0.006)。当使用铁蛋白六分位分组时,铁蛋白与CEVD的相关性变得稍微强一些而且更显著一些(V6 vs V1:校正HR 2.08,p=0.024)。

血清铁与CEVD患病风险的相关性

总而言之,该研究结果表明,血清铁与不同的心血管代谢疾病的相关性不同。血清铁蛋白水平与2型糖尿病的发病风险呈独立地正相关;如果采取较高的铁蛋白水平截止点,铁蛋白水平则还与脑血管疾病发病风险也呈正相关。

 

原始出处:

Suárez-Ortegón, MF., McLachlan, S., Fernandez-Real, JM. et al. Serum ferritin and incident cardiometabolic diseases in Scottish adults. Cardiovasc Diabetol 21, 26 (2022). https://doi.org/10.1186/s12933-022-01450-7.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1761850, encodeId=938a1e6185002, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Sep 24 07:29:39 CST 2022, time=2022-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956350, encodeId=e407195635061, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Jul 30 00:29:39 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004093, encodeId=5a76200409306, content=<a href='/topic/show?id=17a9894e3e5' target=_blank style='color:#2F92EE;'>#血清铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89473, encryptionId=17a9894e3e5, topicName=血清铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 09 23:29:39 CST 2023, time=2023-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939320, encodeId=86f0193932026, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Mar 21 23:29:39 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640062, encodeId=56bc164006288, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 08 13:29:39 CST 2022, time=2022-06-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1761850, encodeId=938a1e6185002, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Sep 24 07:29:39 CST 2022, time=2022-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956350, encodeId=e407195635061, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Jul 30 00:29:39 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004093, encodeId=5a76200409306, content=<a href='/topic/show?id=17a9894e3e5' target=_blank style='color:#2F92EE;'>#血清铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89473, encryptionId=17a9894e3e5, topicName=血清铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 09 23:29:39 CST 2023, time=2023-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939320, encodeId=86f0193932026, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Mar 21 23:29:39 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640062, encodeId=56bc164006288, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 08 13:29:39 CST 2022, time=2022-06-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1761850, encodeId=938a1e6185002, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Sep 24 07:29:39 CST 2022, time=2022-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956350, encodeId=e407195635061, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Jul 30 00:29:39 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004093, encodeId=5a76200409306, content=<a href='/topic/show?id=17a9894e3e5' target=_blank style='color:#2F92EE;'>#血清铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89473, encryptionId=17a9894e3e5, topicName=血清铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 09 23:29:39 CST 2023, time=2023-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939320, encodeId=86f0193932026, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Mar 21 23:29:39 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640062, encodeId=56bc164006288, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 08 13:29:39 CST 2022, time=2022-06-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1761850, encodeId=938a1e6185002, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Sep 24 07:29:39 CST 2022, time=2022-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956350, encodeId=e407195635061, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Jul 30 00:29:39 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004093, encodeId=5a76200409306, content=<a href='/topic/show?id=17a9894e3e5' target=_blank style='color:#2F92EE;'>#血清铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89473, encryptionId=17a9894e3e5, topicName=血清铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 09 23:29:39 CST 2023, time=2023-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939320, encodeId=86f0193932026, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Mar 21 23:29:39 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640062, encodeId=56bc164006288, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 08 13:29:39 CST 2022, time=2022-06-08, status=1, ipAttribution=)]
    2022-03-21 quxin068
  5. [GetPortalCommentsPageByObjectIdResponse(id=1761850, encodeId=938a1e6185002, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Sep 24 07:29:39 CST 2022, time=2022-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956350, encodeId=e407195635061, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Jul 30 00:29:39 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004093, encodeId=5a76200409306, content=<a href='/topic/show?id=17a9894e3e5' target=_blank style='color:#2F92EE;'>#血清铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89473, encryptionId=17a9894e3e5, topicName=血清铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 09 23:29:39 CST 2023, time=2023-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939320, encodeId=86f0193932026, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Mar 21 23:29:39 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640062, encodeId=56bc164006288, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 08 13:29:39 CST 2022, time=2022-06-08, status=1, ipAttribution=)]

相关资讯

这些疼痛可能是心绞痛,要当心!

研究显示约80%以上的冠心病患者在治疗后仍存在心绞痛的症状,严重影响他们的生存质量。

JACC:冠状动脉左主干疾病的预测因素有哪些?

在中度或重度缺血患者中,临床和压力测试参数对CTA上的LMD有中等预测作用。

Circulation:做好简单生活7法则,“逆天改命”不是梦!可增加无冠心病年数高达20年!

Circulation:美国心脏协会的简单生活7法则:生活方式建议,多基因风险和冠心病的终生风险

JAMA子刊:教你吃得身体倍儿棒!15种食物有益心血管健康,10种有害千万少吃,防糖尿病更有效的竟然是酸奶!

JAMA Network Open:本研究确定了15种具有保护性关联的饮食因素和10种具有有害关联的饮食因素,并确定了特定CMD终点。

J Clin Lipidol:在接受他汀类药物治疗的冠心病患者中,较低的LDL-C水平与较低的薄纤维帽粥样斑块发生率相关

近日,发表在《J Clin Lipidol》的一篇研究显示:在他汀类药物治疗的冠状动脉疾病(CAD)患者中,较低的LDL-C水平与罪犯斑块中的薄纤维帽粥样斑块(TCFAs)的较低发生率相关。

AHJ:无症状冠心病植入支架预后如何?研究

COURAGE和ISCHIMA研究提示稳定型冠心病患者与最佳药物治疗相比,血运重建能减轻症状,但不能降低死亡率。那么没有症状的稳定型缺血性心脏病 (SIHD) 患者行PCI治疗预后如何?