Oral Dis:测量唾液中的LDH可以作为筛查口腔癌和口腔潜在恶性疾病的一种有用方法

2022-01-12 MedSci原创 MedSci原创

口腔癌构成了全球公共卫生最相关的挑战之一,在全球所有癌症中排名第17位。唾液中生物标志物的检测是一种诊断工具,由于其非侵入性和简单的方法而被经常使用,而且可以系统地重复,不会给病人带来不适。

口腔癌构成了全球公共卫生最相关的挑战之一,在全球所有癌症中排名第17位。唾液中生物标志物的检测是一种诊断工具,由于其非侵入性和简单的方法而被经常使用,而且可以系统地重复,不会给病人带来不适。近日,发表于Oral Dis的一项研究评估了与健康对照组(CG)相比,口腔癌(OC)或口腔潜在恶性疾病(OPMD)患者的唾液乳酸脱氢酶(LDH)水平是否会增加。

我们对专业数据库(PubMed/MEDLINE、The Cochrane Library、Web of Science、Scopus和OpenGrey)进行了全面搜索,包括评估OC或OPMD患者唾液中LDH水平(单位:UI/L或μ/L)的观察性分析研究,并与CG进行比较。

 

结果,研究人员共纳入了13项病例对照研究。共评估了755名患者,包括303名OC病例,149名OPMD病例和303名对照。荟萃分析显示,OC组内的LDH水平高于CG(SMD 9.49;95% CI 6.97-12;p = .00001)。口腔白斑病患者(SMD 11.67;95% CI 1.01-22.33;p = .03)和口腔粘膜下纤维化患者(SMD 25.83;95% CI -1.74-53.40;p = .07)的水平也高于CG。此外,OC患者的唾液中LDH水平高于口腔白斑病患者(SMD 5.62;95% CI 2.14-9.11;p = .002)。所有被评估的研究中,异质性很高。

综上所述,本系统回顾的结果显示,OC和OPMD患者的唾液中LDH水平高于健康患者。此外,OC的唾液中LDH水平高于OPMD。尽管这一系统回顾存在局限性。有证据表明,测量唾液中的LDH可以作为筛查OPMD和OC的一种有用方法,但需要新的高质量研究来进一步确定精确的截止值。

 

原始出处:

 

Óscar Iglesias-Velázquez, et al., Salivary LDH in oral cancer and potentially malignant disorders: A systematic review and meta-analysis. Oral Dis. 2022 Jan;28(1):44-56. doi: 10.1111/odi.13630.

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    2022-07-06 ms8000001255329993

    科研

    0

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    2022-04-19 小几洁
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    2022-03-18 Super王春笛

    为啥不体内验证下

    0

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