坚持CPAP治疗并不能降低睡眠呼吸暂停患者的患癌风险

2021-09-08 小文子 MedSci原创

OSA患者坚持CPAP治疗并不能降低癌症发病率。

阻塞性睡眠呼吸暂停(OSA)是一种高发性疾病,全球约10亿成人受累。越来越多证据表明OSA与癌症发生风险有关。然而,OSA的一线治疗持续气道正压通气(CPAP)是否能够降低癌症发病率?

近日,发表在European Respiratory Journal 杂志的一篇文章对这一问题进行验证,与非依从性OSA患者相比,坚持CPAP治疗是否与癌症发病率降低有关。

研究纳入诊断性睡眠研究前或CPAP治疗第一年期间无患癌病史、接受CPAP治疗的OSA患者。整个随访期间,未停用CPAP并平均每晚使用4h或更长时间的患者为CPAP依从组;随访期间停止使用CPAP,或每晚使用时间少于4h的患者为非依从组。利用逆概率处理加权法对数据进行分析,以评估CPAP依从性对癌症风险的影响。

研究纳入4499例患者,中位随访时间5.4[3.1-8.0]年。期间,437例(9.7%)患者被诊断出癌症,其中,非依从组有194例(10.7%)(n=1817),依从组有243例(9.1%)(n=2682)。癌症发病率为16.4例/1000人/年(95%CI [14.8, 18.0]),非依从组发病率为17.5例/每1000人/年 [15.0, 20.1],依从组发病率为15.6例/1000人/年[13.7, 17.7]。最终加权模型显示CPAP依从性对全因患癌风险没有影响(sHR=0.94, 95%CI [0.78, 1. 14])

OSA患者坚持CPAP治疗并不能降低癌症发病率。坚持CPAP治疗是否可以降低OSA患者(尤其对于严重夜间低氧血症患者)特定部位癌症风险仍需进一步评估。

原文出处:

Justeau Gégoire, Bailly S, Gervès-Pinquié Cé, et al. Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy. Eur Respir J 2021; in press (https://doi.org/10.1183/13993003.01935-2021).

 

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    2021-09-19 weigq

    OSA与癌症发病率关糸值得进一步研究。

    0

  5. 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    2021-09-10 ms4305551391379490

    受教了

    0

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    2021-09-09 lq0307
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    2021-09-08 天天黑眼圈

    百忧解有哪些不适应症?

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