JNCI:免疫检查点抑制剂治疗的癌症患者的生活质量

2021-09-15 Nebula MedSci原创

接受 ICI 治疗的癌症患者报告的总体生活质量没有明显变化,而且还优于接受非 ICI 方案治疗的患者

免疫疗法因能够延长预后不良的癌症患者的生存时间而引起了广泛的科学和临床兴趣。免疫检查点抑制剂 (ICI,如纳武单抗、帕博利珠单抗、伊匹单抗等)现已被常规用于转移性黑色素瘤、转移性 Merkel细胞癌、非小细胞肺癌(NSCLC)、小细胞肺癌(SCLC)、肝细胞癌、转移性三阴性乳腺癌、头颈鳞状细胞癌、肾细胞癌、霍奇金淋巴瘤、膀胱癌、尿路上皮癌和部分转移性结直肠癌的标准治疗

但是,ICI 的一个特殊挑战是其对患者生活质量(QOL)的影响的不确定性。虽然 ICI 相关试验报道了患者报告的生活质量 (QOL),但这些试验的规模和异质性使得难以进行患者教育。

本研究是一项荟萃分析,旨在概述接受 ICI 治疗的癌症患者的 QOL 和症状的变化。

根据 PRISMA 指南,研究人员从多个数据库中检索了 2019年 11月前发表的报告了接受 ICI 治疗的癌症患者的 QOL 数据的研究。预定的主要终点是接受 ICI 治疗的癌症患者的总体 QOL 的变化和接受 ICI vs 非ICI 积极治疗的患者的总体 QOL 变化的差异。次要终点包括身体功能和症状。

ICI vs 非ICI 治疗组患者的QOL变化差异

筛查了 20323 篇文献,其中 26 篇符合纳入标准。接受 ICI 治疗的癌症患者的总体 QOL 并没有随时间而变化(k=26,n=6974,p=0.019)。与接受非ICI 方案治疗的患者相比,接受 ICI 治疗的患者的总体 QOL 有更大程度的改善(k=16,ICI 组 n=3588,非ICI 组 n=2948,p<0.001)。接受 ICI 治疗的患者的身体功能没有发生明显变化(k=14,n=3169,p=0.47);ICI 组和非ICI 组(k=11,n=4630)之间身体功能的平均变化没有差异(p=0.94)。

在症状方面,接受 ICI 治疗的患者的食欲减退、失眠和疼痛严重程度均有所降低,但呼吸困难严重程度增加(k=14,n=3243-3499,p<0.001)。最后,接受 ICI 治疗的患者的失眠严重程度高于接受非ICI 治疗的患者(k=11,n=4791,p<0.001)。

该研究是最早定量总结接受 ICI 治疗的癌症患者的生活质量的研究之一。研究结果表明,接受 ICI 治疗的癌症患者报告的总体生活质量没有明显变化,而且还优于接受非 ICI 方案治疗的患者

原始出处:

Gonzalez Brian D,Eisel Sarah L,Bowles Kristina E et al. Meta-Analysis of Quality of Life in Cancer Patients Treated with Immune Checkpoint Inhibitors.[J] .J Natl Cancer Inst, 2021, https://doi.org/10.1093/jnci/djab171

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    2021-10-07 jklm09
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    2021-09-19 医者仁者

    🐀🌴🪵

    0

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    2021-09-16 与狼共舞

    学习学习

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    2021-09-15 SR~young海东

    经常学习

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    2021-09-15 1453df99m58暂无昵称

    免疫疗法因能够延长预后不良的癌症患者的生存时间而引起了广泛的科学和临床兴趣。。

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    2021-09-15 JZ Yang

    感谢分享

    0

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