Clini Trans Gastroenterology:年轻人中结直肠癌的发病率上升与肥胖患者手术切除的增加相关

2020-05-03 MedSci原创 MedSci原创

目前有证据表明肥胖与食道癌(EC),胃癌(GC),结直肠癌(CRC)和胰腺癌(PC)有关。但是,尚缺乏测试肥胖与这些癌症发病率的近期时间趋势之间的联系的国家级研究。

背景及目标: 目前有证据表明肥胖与食道癌(EC),胃癌(GC),结直肠癌(CRC)和胰腺癌(PC)有关。但是,尚缺乏测试肥胖与这些癌症发病率的近期时间趋势之间的联系的国家级研究,因此,本项研究旨在探究二者的关系。

方法: 研究人员了查询了目前的EC,GC,CRC和PC的发生率。肥胖症(体重指数≥30kg / m 2)分层的癌症手术是从国家住院样本(NIS)获得的。最后,研究人员使用平均年变化率(AAPC)量化了2002-2013年各年龄段癌症发病率和切除率的趋势。

结果: 在PC的所有年龄段的20-49岁年龄组中,CRC和GC的发生率均增加(AAPC分别为+ 1.5%;+ 0.7%,P <0.001)。相反,在50岁以上的患者以及所有成年人的EC中,CRC和GC的发生率均降低。根据NIS,肥胖患者接受CRC切除术的人数在所有年龄段都有所增加(在18-49岁年龄段患有直肠癌的人群中,最高AAPC为+ 15.3%,P = 0.047)。这种趋势与接受CRC切除的非肥胖患者普遍减少相反。此外,EC,GC和PC切除术仅在50岁以上肥胖的成年人中增加。

结论: 尽管年轻发病的CRC,GC和PC随时间增加,但我们仅发现接受CRC切除的肥胖的年轻成年人相应增加。因此,有可能肥胖的早期发作可能会将CRC的风险转移到了更年轻的患者身上。

原始出处:

Hussan, Hisham. Et al. Rising Incidence of Colorectal Cancer in Young Adults Corresponds With Increasing Surgical Resections in Obese Patients. Clini Trans Gastroenterology.2020.

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    2020-05-28 许安
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CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505005, encodeId=92c21505005fb, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue May 05 07:53:59 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
  5. 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  6. 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Aug 03 04:53:59 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382682, encodeId=f3983826823a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun May 10 21:21:52 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429440, encodeId=b43c142944069, content=<a href='/topic/show?id=bb015438221' target=_blank style='color:#2F92EE;'>#手术切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54382, encryptionId=bb015438221, topicName=手术切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfdd4195665, createdName=s_pl2009, createdTime=Tue May 05 07:53:59 CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453376, encodeId=5fdb14533e639, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue May 05 07:53:59 CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505005, encodeId=92c21505005fb, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue May 05 07:53:59 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-08-03 bsmagic9140
  7. 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CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505005, encodeId=92c21505005fb, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue May 05 07:53:59 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-05-10 wxl882001

    学习一下

    0

  8. 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