Arch Osteoporos:脊柱旁肌肉的脂肪浸润与腰椎骨质密度有关

2020-10-01 MedSci原创 MedSci原创

本研究旨在探讨腰椎旁肌肉脂肪浸润与腰椎骨质密度(BMD)的关系,研究结果已在线发表于Arch Osteoporos。

本研究旨在探讨腰椎旁肌肉脂肪浸润与腰椎骨质密度(BMD)的关系,研究结果已在线发表于Arch Osteoporos。

研究共纳入88名受试者(52名女性,36名男性;年龄,46.6±14.2岁;BMI,23.2±3.49kg/m2)。使用基于化学位移编码的水脂MRI,在L2/3、L3/4和L4/5水平测量脊柱旁肌肉(竖脊肌、多指肌和腰肌)的质子密度脂肪分数(PDFF)。使用定量计算机断层扫描(QCT)评估L1、L2和L3的BMD。使用单因素方差分析检验骨密度正常、骨质疏松和骨质疏松症受试者之间的脊柱旁肌PDFF的差异。采用线性回归与年龄、性别、BMI变量分析了耻骨旁肌PDFF与QCT-BMD的关系。

 

结果显示,骨密度正常的受试者的竖脊肌、多头肌、腰肌的PDFF均显著低于骨质减少和骨质疏松症患者(均P<0.001)。校正了年龄、性别、BMI后,脊柱旁肌PDFF与骨密度呈负相关(标准化β系数,- 0.21~- 0.29;均P < 0.05)。

 

综上所述,该研究结果表明,校正年龄、性别和BMI后,椎旁肌脂肪浸润增加,而腰椎BMD降低。脊柱旁肌肉和椎体是相互作用的组织。脊柱旁肌肉脂肪浸润可能是低腰椎BMD的标志。化学移位成像是一种高效、快速的定量方法,当患者在进行常规腰椎MRI检查时,伴有腰背痛时,可以很容易地将其加入临床方案,以测量腰椎旁肌肉PDFF。

 

原始出处:

 

Yinxia ZhaoMingqian Huang, et al., Fatty infiltration of paraspinal muscles is associated with bone mineral density of the lumbar spine. Arch Osteoporos. 2019 Oct 15;14(1):99. doi: 10.1007/s11657-019-0639-5.

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    2021-02-25 tidiq
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    2020-10-03 lsndxfj
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    2020-10-03 Eleven17

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