Stroke: ICH后白细胞升高与血肿扩大减少相关

2016-07-24 phylis 译 MedSci原创

背景:急性白细胞增多是急性脑出血(ICH)的一种反应。白细胞,因为它们与血小板和凝血因子的相互作用,可能会在止血中发挥作用。研究者调查入院白细胞增多是否与急性脑出血后出血减少相关。方法:前瞻性收集从1994至2015原发性脑出血的患者,对其进行回顾性分析。研究包括随访中的CT扫描和症状开始后48小时内的白细胞计数。应用半自动软件计算基线和随访中的血肿体积,血肿扩大定义为体积增大>30%或6mL。应

背景:急性白细胞增多是急性脑出血(ICH)的一种反应。白细胞,因为它们与血小板和凝血因子的相互作用,可能会在止血中发挥作用。研究者调查入院白细胞增多是否与急性脑出血后出血减少相关。

方法:前瞻性收集从1994至2015原发性脑出血的患者,对其进行回顾性分析。研究包括随访中的CT扫描和症状开始后48小时内的白细胞计数。应用半自动软件计算基线和随访中的血肿体积,血肿扩大定义为体积增大>30%或6mL。应用多因素Logistic回归分析调查血白细胞计数与脑出血血肿扩大的相关性。

结果:共有1302名受试者符合资格标准(平均年龄为75岁;55.8%为男性),其中207例(15.9%)有血肿扩大。入院时高白细胞计数与血肿扩大风险减少相关(每增加1000细胞的OR : 0.91;95%CI,0.86-0.96)。血肿扩大的风险与中性粒细胞计数呈负相关(OR,0.90;95%CI,0.85-0.96;P = 0.001),和单核细胞计数直接相关(OR,2.71;95%CI,1.08-6.83;)。淋巴细胞计数和ICH血肿扩大没有明显相关性(OR,0.96;95%CI,0.79-1.17)。

结论:较高的入院白血细胞计数与血肿扩张的风险较低相关。研究结果强调急性ICH后,炎症反应在调节凝血级联反应中的作用。

原始出处:

Morotti A, Phuah CL, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016 Jun.


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文,值得推荐。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-07-26 diushouji
  4. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]

相关资讯

Sci Rep:循环内皮祖细胞水平升高与脑出血患者良好功能预后相关

循环内皮祖细胞(EPCs)在损伤脑组织再生中发挥作用。然而,循环EPC水平与脑出血(ICH)功能恢复的关系尚未研究。因此,研究者旨在研究循环内皮祖细胞脑出血预后的影响。406例发病在12 小时内的原发性脑出血(男,71.7%岁,10.8年;72.7 ± )纳入前瞻性研究。。主要预后变量是12个月良好功能结局(改良Rankin量表≤2),6个月残余量作为辅助变量。通过流式细胞仪检测,入院,72h及7

J Neurosurg:尿激酶对治疗脑出血可能有特殊作用

西南医院神经外科团队经过多年科研终于证实,尿激酶在治疗脑出血中具有特殊作用。此项科研成果已在国际权威期刊《神经外科杂志》上刊载。目前,在微创治疗脑出血手术中,最常用的纤溶药物是组织纤溶酶原激活物(tPA),它可使脑内淤血形成的“血块”很快消融,以便医生将其尽快清除干净。但它价格较昂贵,不仅给患者带来较大经济压力,并有研究证明tPA可能引起迟发脑水肿以及神经损伤。尿激酶项目研究负责人、973计划首席

Lancet:大数据看中风的预防(INTERSTROKE试验)

最近麦克马斯特大学的研究者称,全世界90%的中风,发病原因大致可以归结为10个,但是十个致病因素会因为地域的不同而所占的比例也有差别。近期发表在《柳叶刀》(The Lancet )杂志上的文章表明,中风的预防是目前中风最紧迫的事情,但是地域差异性会影响预防策略的实施。中风是引起死亡和残疾的主要原因,尤其是对于中低收入人群来说,中风的两种形式包括由于血栓引起的缺血性中风,大概占到85%;另外一种是脑

JNS:我国科学家发现尿激酶对治疗脑出血有特殊作用

日前从重庆市西南医院获悉,西南医院神经外科团队经过多年科研终于证实,尿激酶在治疗脑出血中具有特殊作用。此项科研成果已在国际权威期刊《神经外科杂志》上刊载。 目前,在微创治疗脑出血手术中,最常用的纤溶药物是组织纤溶酶原激活物(tPA),它可使脑内淤血形成的“血块”很快消融,以便医生将其尽快清除干净。但它价格较昂贵,不仅给患者带来较大经济压力,并有研究证明tPA可能引起迟发脑水肿以及神经损伤。 尿激酶

Neurology:原发性脑出血前,血脂水平呈亚急性下降

目的:研究者旨在描述在脑出血(脑出血)患者的循环血脂水平的时间变化,并探讨其与脑出血风险。方法:这是一项单中心、回顾性,纵向的病例对照研究,原发性脑出血和对照组受试者来源于医院临床数据登记记录。应用分段线性混合效应随机系数模型,以确定血脂变化对脑出血风险的影响。结果:212例脑出血病例和301例对照组患者纳入分析。,脑出血患者和非脑出血组对照组血清总胆固醇(TC)和低密度脂蛋白(LDL)水平的总体

Stroke: 脑出血不规则的形状与预后独立相关(INTERACT2试验)

背景:急性脑出血患者,血肿的形态和密度与其随后的增长相关,但这些因素对临床预后的影响不确定的。方法: 急性脑出血强化降压(INTERACT2)试验中获得CT扫描和临床资料。三个独立的神经学家应用量表独立的评估ICH的形状和密度。当ICH存在≥2椭球形ICH,定义为不规则形状。ICH时存在≥3低密度病灶,定义为密度不均匀。预后为90天随机化后,死亡和重大残疾(改良Rankin量表评分3-5分)。应用