Lancet:派姆单抗单药二线治疗胃以及胃食管交界癌效果不佳

2018-06-05 zhangfan MedSci原创

研究发现,对于进展期胃以及胃食道交界癌患者,派姆单抗二线治疗的效果较紫杉醇相比在延长患者生存期方面不显著

进展期胃或胃食管交界癌患者化疗效果普遍不佳。近日研究人员考察了派姆单抗对铂-氟嘧啶一线治疗后进展的胃或胃食管交界癌的疗效。

本次III期临床研究在30个国家,148个医疗中心开展,参与者PD-L1表达阳性且CPS得分1分以上。患者随机接受每3周200mg的派姆单抗或紫杉醇,至多持续2年。研究的主要终点是总生存期以及无进展生存。

395名患者参与研究,其中196人接受派姆单抗,199人接受紫杉醇。2年后,326名患者死亡,其中派姆单抗组151人,紫杉醇组175人,死亡率77% vs 88%。派姆单抗组患者平均生存期9.1个月vs紫杉醇组8.3个月,无进展生存期派姆单抗组1.5个月vs紫杉醇组4.1个月。派姆单抗组42人(14%)以及紫杉醇组96人(35%)出现3-5级的治疗不良事件。

研究发现,对于进展期胃以及胃食道交界癌患者,派姆单抗二线治疗的效果较紫杉醇相比在延长患者生存期方面不显著。

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    2018-10-24 howi
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    2018-06-07 wzb521zf

    一起学习学习

    0

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  5. 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createdName=健康达人, createdTime=Tue Jun 05 16:17:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321683, encodeId=bd6a321683e8, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jun 05 13:46:52 CST 2018, time=2018-06-05, status=1, ipAttribution=)]
    2018-06-07 zhouqu_8
  6. 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  7. 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  8. 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createdName=健康达人, createdTime=Tue Jun 05 16:17:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321683, encodeId=bd6a321683e8, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jun 05 13:46:52 CST 2018, time=2018-06-05, status=1, ipAttribution=)]
    2018-06-06 cscdliu

    学习了.谢#谢

    0

  9. 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createdName=健康达人, createdTime=Tue Jun 05 16:17:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321683, encodeId=bd6a321683e8, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jun 05 13:46:52 CST 2018, time=2018-06-05, status=1, ipAttribution=)]
    2018-06-05 健康达人

    肿瘤免疫是大家关心的话题,K药与其它药对比,值得关注!

    0

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