Ann Rheum Dis:银屑病关节炎患者关节手术的发生率和时间趋势

2019-07-22 xiangting MedSci原创

1996年至2012年间,与GPC相比,PsA患者关节手术的发生率仍高两倍。

这项研究旨在探讨与一般人群相比,银屑病关节炎(PsA)患者关节手术的时间趋势和累积发生率。

在这项全国性、基于登记的队列研究中,使用丹麦国家患者登记确定偶发性PsA患者。在四个日期定义的队列中计算关节手术的5年发生率(IR)和发病率比率(IRR)。每名患者与来自一般人群队列(GPC)的10名非PsA个体进行匹配。使用Aalen-Johansen方法分别估算任意关节手术和关节牺牲术的累积发生率。

1996年至2017年,共登记了11960名PsA患者(平均年龄50岁;女性占57%)。在所有时间段内,PsA患者关节手术的IRR是GPC的两倍。在PsA患者中,诊断后5年、10年和15年,分别有2%、10%和29%需要进行关节手术。随访15年后,诊断时年龄18-40岁的PsA患者手术风险(22%)高于60岁以上的GPC(20%)。

1996年至2012年间,与GPC相比,PsA患者关节手术的发生率仍高两倍。经过15年的随访,近30%的PsA患者接受了手术,即使是18-40岁诊断为PsA的患者,其手术风险也高于60岁以上的GPC。因此,手术率高代表了目前PsA治疗中未被满足的需求。

原始出处:

Jorgen Guldberg-Moller. Incidence and time trends of joint surgery in patients with psoriatic arthritis: a register-based time series and cohort study from Denmark. Ann Rheum Dis. 12 July 2019.

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    2019-07-24 lmm397