肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

Blood：不同LBCL亚型间的分子异质性

2019-11-20 QQY MedSci原创

LBCLHGBCLDLBCL
关注

儿童大B细胞淋巴瘤(LBCL)具有与成人患者相同的形态学和表型特征，但预后较好。在儿童中高频出现的某些亚型如携带IRF4重排的LBCL(LBCL-IRF4)，提示可能存在年龄相关的生物学差异。为研究这些肿瘤的遗传和分子异质性，研究人员招募了31位弥漫性大B细胞淋巴瘤(DLBCL)患者、20位LBCL-IRF4患者和12位高级别B细胞淋巴瘤 (HGBCL）患者（≤25岁），对其进行靶基因测序、拷

中心点：

携带IRF4重排的LBCL的突变特征与其他儿童和青年LBCL患者的不同。

年龄、高遗传复杂性、ABC细胞来源和TP53突变均与儿童和青年LBCL患者的不良EFS相关。

摘要：

儿童大B细胞淋巴瘤(LBCL)具有与成人患者相同的形态学和表型特征，但预后较好。在儿童中高频出现的某些亚型如携带IRF4重排的LBCL(LBCL-IRF4)，提示可能存在年龄相关的生物学差异。

为研究这些肿瘤的遗传和分子异质性，研究人员招募了31位弥漫性大B细胞淋巴瘤(DLBCL)患者、20位LBCL-IRF4患者和12位高级别B细胞淋巴瘤 (HGBCL）患者（≤25岁），对其进行靶基因测序、拷贝数分析和基因表达谱分析。

每个亚组均表现出不同的分子特征。LBCL-IRF4患者常见IRF4基因和NF-κB信号通路基因(CARD11、CD79B和MYD88)突变、17p13缺失和7号染色体11q12.3-q25扩增，而DLBCL患者，主要是生发中心B细胞（GCB）亚型，携带的基因突变与成人患者的相似（如SOCS1和KMT2D），2p16/REL扩增和19p13/CD70缺失。HGBCL亚型表现为伯基特淋巴瘤相关基因突变，如MYC、ID3和DDX3X，以及9p21/CDKN2A纯合缺失，而其他病例的遗传特征与GCB-DLBCL的相近。

预后不良相关因素有＞18岁、B细胞DLBCL谱激活、HGBCL、NOS、高遗传复杂性和TP53/MYC突变。

总而言之，本研究进一步揭示了儿童/青年LBCL患者的分子异质性，有助于提高这类患者的分类，为其风险分层提高新的参数。

原始出处：

Joan Enric Ramis-Zaldivar， et al.IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults.Blood.2019002699.https：//doi.org/10.1182/blood.2019002699

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1925054, encodeId=00a11925054ba, content=<a href='/topic/show?id=14553160087' target=_blank style='color:#2F92EE;'>#分子异质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31600, encryptionId=14553160087, topicName=分子异质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Jul 19 04:09:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021242, encodeId=7afd202124235, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Fri Mar 27 03:09:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375593, encodeId=f5663e559380, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Nov 21 05:46:31 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375587, encodeId=58e93e558770, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Nov 21 00:46:38 CST 2019, time=2019-11-21, status=1, ipAttribution=)]
    2020-07-19 liubm555

    #分子异质性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1925054, encodeId=00a11925054ba, content=<a href='/topic/show?id=14553160087' target=_blank style='color:#2F92EE;'>#分子异质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31600, encryptionId=14553160087, topicName=分子异质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Jul 19 04:09:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021242, encodeId=7afd202124235, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Fri Mar 27 03:09:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375593, encodeId=f5663e559380, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Nov 21 05:46:31 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375587, encodeId=58e93e558770, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Nov 21 00:46:38 CST 2019, time=2019-11-21, status=1, ipAttribution=)]
    2020-03-27 ms7258648636991762

    #LBCL#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1925054, encodeId=00a11925054ba, content=<a href='/topic/show?id=14553160087' target=_blank style='color:#2F92EE;'>#分子异质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31600, encryptionId=14553160087, topicName=分子异质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Jul 19 04:09:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021242, encodeId=7afd202124235, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Fri Mar 27 03:09:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375593, encodeId=f5663e559380, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Nov 21 05:46:31 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375587, encodeId=58e93e558770, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Nov 21 00:46:38 CST 2019, time=2019-11-21, status=1, ipAttribution=)]
    2019-11-21 1e1c07bdm01(暂无匿称)

    好

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1925054, encodeId=00a11925054ba, content=<a href='/topic/show?id=14553160087' target=_blank style='color:#2F92EE;'>#分子异质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31600, encryptionId=14553160087, topicName=分子异质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Jul 19 04:09:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021242, encodeId=7afd202124235, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Fri Mar 27 03:09:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375593, encodeId=f5663e559380, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Nov 21 05:46:31 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375587, encodeId=58e93e558770, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Nov 21 00:46:38 CST 2019, time=2019-11-21, status=1, ipAttribution=)]
    2019-11-21 飛歌

    学习了很有用不错

    0