Clinica Chimica Acta:动脉瘤性蛛网膜下腔出血患者血清可溶性凝集素样氧化低密度脂蛋白受体-1浓度与预后的研究

2020-02-18 Gladiator MedSci原创

既往研究表明,氧化低密度脂蛋白(ox-LDL)及其受体凝集素样ox-LDL受体-1 (LOX-1)参与动脉粥样硬化的发病机制。LOX-1在兔蛛网膜下腔出血(SAH)的基底动脉壁表达明显升高。本研究探讨人动脉瘤性SAH后血清可溶性LOX-1浓度与功能预后的关系。

既往研究表明,氧化低密度脂蛋白(ox-LDL)及其受体凝集素样ox-LDL受体-1 (LOX-1)参与动脉粥样硬化的发病机制。LOX-1在兔蛛网膜下腔出血(SAH)的基底动脉壁表达明显升高。本研究探讨人动脉瘤性SAH后血清可溶性LOX-1浓度与功能预后的关系。

本研究纳入94名动脉瘤性SAH患者和94名健康对照组。用酶联免疫吸附试剂盒测定血清可溶性毒素-1浓度。格拉斯哥预后评分为1-3分。

研究结果显示,中位数的值在中风患者血清可溶性LOX-1明显高于对照组(1.5 vs 0.4 ng / ml, P < 0.001)30名患者(31.9%)在卒中6个月时结局较差。血清可溶性LOX-1是不良结局的有力预测指标(OR 5.2095CI 1.25-22.04)。 血清可溶性LOX-1浓度具有明显的区分能力(曲线下面积0.81195%置信区间0.717-0.884)。世界神经外科医师联合会等级,Hunt-Hess等级,改良的Fisher等级和血清可溶性LOX-1浓度的预测能力具有可比性(所有P> 0.05)。

研究结果表明,血清可溶性LOX-1有可能成为人动脉瘤性SAH后的一种有前景的预后预测因子。

原始出处:

Qun LinHua-Jun BaSerum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage

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    2020-12-31 windight
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