NEJM:MERS-CoV可引起院内感染

2013-08-02 青楚 cmt

MERS-CoV即新型中东冠状病毒,在2012年9月被首次报道。沙特阿拉伯学者的一项研究显示,MERS-CoV可人传人,并已在当地的一间医院出现院内爆发。在统计期间共出现23个病例,其中21个为院内获得。除此之外,亦有医务人员感染。这种情况可带来较大的死亡负担。相关论文2013年8月1日在线发表于《新英格兰医学杂志》(NEJM)。 该研究记录了临床和人口统计学信息,并确定潜在的接触和暴露。患者和

MERS-CoV即新型中东冠状病毒,在2012年9月被首次报道。沙特阿拉伯学者的一项研究显示,MERS-CoV可人传人,并已在当地的一间医院出现院内爆发。在统计期间共出现23个病例,其中21个为院内获得。除此之外,亦有医务人员感染。这种情况可带来较大的死亡负担。相关论文2013年8月1日在线发表于《新英格兰医学杂志》(NEJM)。

该研究记录了临床和人口统计学信息,并确定潜在的接触和暴露。患者和接触者均受访,评估潜伏期和间隔(传播链中相继出现症状的时间),并对病毒RNA进行测序 。

结果显示,在2013年4月1日到5月23日之间,在沙特东部省份共报道了23例MERS-CoV感染病例。症状包括高烧20例(87%)、咳嗽20例(87%)、气短11例(48%)和胃肠道症状8例(35%)。20例患者(87%)出现 胸部X线检查异常 。到6月12日为止,共有15例患者 (65%)死亡,6例(26%)恢复,2例(9%)还在住院。平均潜伏期为5.2天(95%CI为 1.9-14.7),间隔期为7.6天(95% CI为2.5-23.1)。共有21例患者是在血透室或住院部经人传播感染。在217例家庭接触者和200多位接触患者的医务工作者中,MERS-CoV感染了5位家庭成员(3例为实验室确诊病例)和2位医务人员(均为实验室确诊)。

Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, Alabdullatif ZN, Assad M, Almulhim A, Makhdoom H, Madani H, Alhakeem R, Al-Tawfiq JA, Cotten M, Watson SJ, Kellam P, Zumla AI, Memish ZA; the KSA MERS-CoV Investigation Team.Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus.N Engl J Med. 2013 Aug;369(5):407-416. Epub 2013 Jun 19.

PMID:
23782161

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1878061, encodeId=267718e8061f8, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Nov 22 17:51:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773405, encodeId=88dc1e7340577, content=<a href='/topic/show?id=de541156efa' target=_blank style='color:#2F92EE;'>#MERS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11567, encryptionId=de541156efa, topicName=MERS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8b838519264, createdName=meichuangyi, createdTime=Sun Jul 13 23:51:00 CST 2014, time=2014-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338397, encodeId=24e4133839e4e, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435197, encodeId=5849143519ed0, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]
    2013-11-22 anminleiryan
  2. [GetPortalCommentsPageByObjectIdResponse(id=1878061, encodeId=267718e8061f8, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Nov 22 17:51:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773405, encodeId=88dc1e7340577, content=<a href='/topic/show?id=de541156efa' target=_blank style='color:#2F92EE;'>#MERS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11567, encryptionId=de541156efa, topicName=MERS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8b838519264, createdName=meichuangyi, createdTime=Sun Jul 13 23:51:00 CST 2014, time=2014-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338397, encodeId=24e4133839e4e, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435197, encodeId=5849143519ed0, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1878061, encodeId=267718e8061f8, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Nov 22 17:51:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773405, encodeId=88dc1e7340577, content=<a href='/topic/show?id=de541156efa' target=_blank style='color:#2F92EE;'>#MERS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11567, encryptionId=de541156efa, topicName=MERS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8b838519264, createdName=meichuangyi, createdTime=Sun Jul 13 23:51:00 CST 2014, time=2014-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338397, encodeId=24e4133839e4e, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435197, encodeId=5849143519ed0, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1878061, encodeId=267718e8061f8, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Nov 22 17:51:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773405, encodeId=88dc1e7340577, content=<a href='/topic/show?id=de541156efa' target=_blank style='color:#2F92EE;'>#MERS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11567, encryptionId=de541156efa, topicName=MERS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8b838519264, createdName=meichuangyi, createdTime=Sun Jul 13 23:51:00 CST 2014, time=2014-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338397, encodeId=24e4133839e4e, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435197, encodeId=5849143519ed0, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Aug 04 05:51:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]

相关资讯

MERS比SARS传染性低但更危险

据法国《费加罗报》网站7月26日报道,最新研究表明,新型冠状病毒MERS-CoV传染性更低,但危险性却强于非典病毒,后者曾于2003年在亚洲造成约800人死亡。 MERS-CoV病毒最早出现于2012年的中东,当时它还属于科学技术远未探知的领域,但随着相关研究的跟进,权威医疗杂志《柳叶刀》也于周五公布相关信息,提出假说认为该类病原体的增殖与传播比2003年在亚洲造成800余患者死亡的非典缓慢得多