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JAMA：FEV1/FVC与COPD相关不良事件风险

2019-06-26 MedSci MedSci原创

FEV1/FVCCOPD慢性阻塞性肺病
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研究认为，将气流阻塞定义为FEV1/FVC低于0.70是临床中诊断COPD准确依据，可显著降低相关疾病的不良预后风险

根据现行指南，慢性阻塞性肺疾病(COPD)的诊断要求第一秒钟用力呼气量与用力肺活量(FEV1：FVC)的比值小于0.70，近日研究人员对FEV1、FEV1/FVC对COPD相关住院和死亡率的预测作用进行了考察。

45-102岁的参与者，接受FEV1以及FVC测试，气流阻塞的定义为FEV1/FVC＜0.65-0.75或全球肺功能参考方程式（LLN）定义的正常值下限。研究的主要终点为COPD住院和COPD相关死亡率。

24 207名成人，平均年龄63岁，12990（54%）名女性， 77%完成随访。期间3925名参与者在340757个随访年中发生了COPD相关事件（发生率为11.5/1000人-年），包括3563例COPD相关住院和447例COPD相关死亡。关于COPD相关事件的鉴别，FEV1/FVC最佳固定阈值0.71与0.70阈值无显著差异（差异：0.001），但比LLN阈值更准确（差异：0.034）。0.70阈值在吸烟者的亚组中准确性最高。

研究认为，将气流阻塞定义为FEV1/FVC低于0.70是临床中诊断COPD准确依据，可显著降低相关疾病的不良预后风险。

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    2019-09-12 yige2004

    #不良事件风险#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2007399, encodeId=6a9e200e399e9, content=<a href='/topic/show?id=609c2048199' target=_blank style='color:#2F92EE;'>#不良事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20481, encryptionId=609c2048199, topicName=不良事件风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Sep 12 19:53:00 CST 2019, time=2019-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738220, encodeId=1d0e1e38220c0, content=<a href='/topic/show?id=649ee364cc' target=_blank style='color:#2F92EE;'>#FEV1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7364, encryptionId=649ee364cc, topicName=FEV1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c43f34388205, createdName=12498761m67暂无昵称, createdTime=Sat Jun 29 11:53:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058463, encodeId=959320584638a, content=<a href='/topic/show?id=1b69e363bb' target=_blank style='color:#2F92EE;'>#FEV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7363, encryptionId=1b69e363bb, topicName=FEV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Tue Dec 24 04:53:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634211, encodeId=64eb163421156, content=<a href='/topic/show?id=735ee36595' target=_blank style='color:#2F92EE;'>#FEV1/FVC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7365, encryptionId=735ee36595, topicName=FEV1/FVC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9ad22108566, createdName=anan, createdTime=Mon Sep 16 17:53:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-06-29 12498761m67暂无昵称

    #FEV1#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2007399, encodeId=6a9e200e399e9, content=<a href='/topic/show?id=609c2048199' target=_blank style='color:#2F92EE;'>#不良事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20481, encryptionId=609c2048199, topicName=不良事件风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Sep 12 19:53:00 CST 2019, time=2019-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738220, encodeId=1d0e1e38220c0, content=<a href='/topic/show?id=649ee364cc' target=_blank style='color:#2F92EE;'>#FEV1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7364, encryptionId=649ee364cc, topicName=FEV1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c43f34388205, createdName=12498761m67暂无昵称, createdTime=Sat Jun 29 11:53:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058463, encodeId=959320584638a, content=<a href='/topic/show?id=1b69e363bb' target=_blank style='color:#2F92EE;'>#FEV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7363, encryptionId=1b69e363bb, topicName=FEV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Tue Dec 24 04:53:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634211, encodeId=64eb163421156, content=<a href='/topic/show?id=735ee36595' target=_blank style='color:#2F92EE;'>#FEV1/FVC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7365, encryptionId=735ee36595, topicName=FEV1/FVC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9ad22108566, createdName=anan, createdTime=Mon Sep 16 17:53:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-12-24 circumcision

    #FEV#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2007399, encodeId=6a9e200e399e9, content=<a href='/topic/show?id=609c2048199' target=_blank style='color:#2F92EE;'>#不良事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20481, encryptionId=609c2048199, topicName=不良事件风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Sep 12 19:53:00 CST 2019, time=2019-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738220, encodeId=1d0e1e38220c0, content=<a href='/topic/show?id=649ee364cc' target=_blank style='color:#2F92EE;'>#FEV1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7364, encryptionId=649ee364cc, topicName=FEV1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c43f34388205, createdName=12498761m67暂无昵称, createdTime=Sat Jun 29 11:53:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058463, encodeId=959320584638a, content=<a href='/topic/show?id=1b69e363bb' target=_blank style='color:#2F92EE;'>#FEV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7363, encryptionId=1b69e363bb, topicName=FEV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Tue Dec 24 04:53:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634211, encodeId=64eb163421156, content=<a href='/topic/show?id=735ee36595' target=_blank style='color:#2F92EE;'>#FEV1/FVC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7365, encryptionId=735ee36595, topicName=FEV1/FVC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9ad22108566, createdName=anan, createdTime=Mon Sep 16 17:53:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 anan

    #FEV1/FVC#

    0