JAHA:供体肥胖对心脏移植术后结局的影响

2018-12-04 xing.T MedSci原创

由此可见,该研究表明与接受正常体重供体移植物患者相比,接受较高BMI供体心脏患者可能不会在移植后的短期内死亡风险增加。

尚未有研究探究供体肥胖对原位心脏移植结局的影响。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是探究供体肥胖对成人原位心脏移植受者结局的影响。

该研究的数据来自联合网络器官共享数据库。所有成人(年龄≥18岁)患者在2000年至2016年期间接受了原位心脏移植(n=31920)。研究人员按照供体体重指数(BMI)对队列进行分层;13015例(40.8%)患者接受正常体重供体(BMI为18.5-24.9)心脏,11271例(35.3%)患者接受超重(BMI为25.0-29.9)供体心脏,4910例(15.4%)患者接受了肥胖(BMI为30.0-34.9)捐赠者的心脏,2724名(8.5%)患者接受了来自极度肥胖(BMI≥35)捐赠者的心脏。肥胖供体群体较老,包括较高的糖尿病发病率,并且肌酐水平较高。

研究人员的数据还显示肥胖供体移植物的接受者年龄较大,BMI、肌酐、糖尿病百分比较高和总等待时间较长。基于供体BMI的分类组别,在患者的存活可能性检测不到显著差异(P=0.08)。在调整后的生存分析中,四组的总生存概率没有显著差异(P=0.25)。

由此可见,该研究表明与接受正常体重供体移植物患者相比,接受较高BMI供体心脏患者可能不会在移植后的短期内死亡风险增加。

原始出处:

Yasuhiro Shudo.et al.Impact of Donor Obesity on Outcomes After Orthotopic Heart Transplantation.JAHA.2018.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.010253

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    2019-01-27 cy0324
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    2019-06-29 feather85
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    2018-12-06 zhaohui6731