J Clin Endocrinol Metab:远离二手烟,还孩子以骨健康

2019-02-19 国际糖尿病编辑部 国际糖尿病

一项纵向分析结果显示,与童年期未接触尼古丁的成人相比,父母吸烟的儿童更有可能在成年后表现出骨骼健康受损,包括骨量减少、骨密度降低和更多低能量骨折。

一项纵向分析结果显示,与童年期未接触尼古丁的成人相比,父母吸烟的儿童更有可能在成年后表现出骨骼健康受损,包括骨量减少、骨密度降低和更多低能量骨折。

芬兰图尔库大学内科教授Markus Juonala博士表示,儿童期被动吸烟可能会对骨骼健康产生长期影响,应该尽一切努力减少儿童接触烟雾的机会。

Juonala及其同事对年轻芬兰人血管风险研究中1422例受试者数据进行了分析,该研究从1980年开始,对一组儿童进行了为期28年的追踪调查。基线时,受试者的父母自行报告吸烟情况。研究者在基线采集血样以测定血清可替宁水平,非吸烟者在3~20 ng/ml被认为是被动接触尼古丁阳性。将受试者按尼古丁暴露水平分成3组:父母不吸烟和检测不到可替宁水平、父母吸烟和检测不到可替宁水平(定义为“卫生吸烟”)、父母吸烟和可检测到可替宁水平(定义为“不卫生吸烟”)。受试者成年后,通过胫骨和桡骨周围定量CT测量其骨骼特征,并通过定量超声评估跟骨矿物质密度。骨折通过问卷进行自我报告。研究者在线性回归模型中使用父母吸烟、血清可替宁和父母卫生吸烟作为暴露变量,检验儿童被动吸烟对骨骼指标的影响。

研究者发现,儿童期被动吸烟(可替宁水平升高)与骨量指数z评分(P=0.0003)、骨量(P=0.003)、骨密度(P=0.0001)、骨面积(P=0.81)和骨应变z评分(P=0.003)呈负相关。在校正出生体重、成年期吸烟或排除成年期主动吸烟者之后,结果仍持续存在。

儿童期可替宁水平升高的受试者成年期低能量骨折率也高于低可替宁水平者(14.3%vs.11.3%;P=0.15)。

在父母卫生吸烟分层分析中,研究者发现,父母不卫生吸烟的儿童骨量指数z评分低于父母卫生吸烟的儿童(P=0.008)。

研究者指出,研究中对父母吸烟和儿童血清可替宁水平的检查只有1次,但年龄的相互作用未被检测到,这表明单次测量可能能够代表儿童暴露情况。

Juonala认为,了解被动吸烟是否与骨质疏松性骨折有关也很有必要。

原始出处:
Markus Juonala, et al. Childhood exposure to passive smoking and bone health in adulthood. The Cardiovascular Risk in Young Finns Study. Journal of Clinical Endocrinology & Metabolism. Feb 2019.

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    2019-12-12 一闲
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    2019-08-24 guojianrong
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    2019-02-21 aids215
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    2019-02-19 1253d384m28暂无昵称

    二手烟还可能损害肺部,长期吸入二手烟还可能致癌!

    0

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近期,加州大学戴维斯分校科学家的研究结果显示,通常水平的连续室内二手烟暴露,将会引起小鼠心脏细胞功能变化,更易出现心脏电交替,这是心律失常和心源性猝死的前兆。相关研究论文发表在《环境健康展望》杂志上。