JCO:曲妥珠单抗联合多西紫杉醇治疗晚期涎腺导管癌

2018-11-29 MedSci MedSci原创

晚期涎腺导管癌(SDC)较为罕见,尚缺乏能够证明全身治疗有效性的临床证据。JCO近期发表了一篇文章,评估曲妥珠单抗联合多西紫杉醇治疗局部晚期和/或复发或转移性HER-2阳性SDC患者的疗效和毒性。

晚期涎腺导管癌(SDC)较为罕见,尚缺乏能够证明全身治疗有效性的临床证据。JCO近期发表了一篇文章,评估曲妥珠单抗联合多西紫杉醇治疗局部晚期和/或复发或转移性HER-2阳性SDC患者的疗效和毒性。

该研究是一项日本的单中心II期研究。患者接受曲妥珠单抗治疗,初始剂量为8 mg / kg,后每3周接受6 mg / kg。每3周接受多西紫杉醇70mg / m 2。主要研究终点是总缓解率; 次要终点包括临床获益率,无进展生存期,总生存期和毒性。研究最终招募了57名符合条件的SDC患者。总缓解率为70.2%,临床获益率为84.2%。中位无进展和总生存时间分别为8.9个月和39.7个月。最常见的不良反应是贫血,其次是白细胞计数减少和中性粒细胞减少症。最常见的4级不良反应是中性粒细胞计数减少。8名患者(14%)出现3级发热性中性粒细胞减少症。没有大于等于2级的心力衰竭不良事件,也未出现左心室射血分数下降至小于50%。

文章最后认为,该研究数据表明曲妥珠单抗联合多西紫杉醇治疗HER-2阳性SDC患者的疗效较为理想,毒性可控。

原始出处:

Hideaki Takahashi, Yuichiro Tada, et al. Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Salivary Duct Carcinoma. JCO. November 2018 doi: 10.1200/JCO.18.00545

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    2019-10-26 lidong40
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    2018-11-29 天地飞扬

    了解一下,谢谢分享!

    0