BMC Pregnancy and Childbirth:母乳喂养或能降低高风险儿童的哮喘患病率

2018-08-28 佚名 BMC

最近发表在开放获取期刊《BMC妊娠与生育》(BMC Pregnancy and Childbirth)上的一项研究发现,如果母亲孕期使用过抗生素,孩子患哮喘的风险会升高,但如果母亲能够在孩子出生后的6个月内进行纯母乳喂养,这种风险就会被降低。



上海交通大学医学院附属新华医院张军教授说:“近30年来,儿童哮喘的患病率呈现明显的上升趋势。探索儿童哮喘的病因很重要,但积极寻找有助于预防儿童哮喘发生的保护性因素对改善病人的健康一样重要。此前的研究表明,延长母乳喂养的时间和纯母乳喂养都可能有助于预防儿童过敏性疾病(包括哮喘)的发生,所以我们想要进一步探索母乳喂养在高风险儿童中——尤其是那些母亲孕期使用过抗生素的儿童中——是否也有保护作用。”

研究者们发现,在母亲孕期有过抗生素暴露的孩子患哮喘的几率是没有抗生素暴露的儿童的1.7倍。这其中,男孩和有过敏性疾病家族史的儿童风险尤其高,分别是没有抗生素暴露的儿童的2.2倍和3.1倍。但这种风险只存在于出生后6个月内未给予纯母乳喂养的儿童中,而那些虽然有抗生素暴露但给予纯母乳喂养的儿童并没有表现出额外的哮喘风险。

张教授说:“我们的发现对孕期抗生素的使用有重要的指导意义,同时有助于推动6月龄内婴儿的纯母乳喂养——这一点尤为重要,因为我国目前6月龄内婴儿纯母乳喂养率仍然较低。”

作者们于2015年6月至2016年1日在上海进行了病例对照研究。一共有634名患哮喘的儿童和864名未患哮喘的儿童参与了研究,所有参与儿童均在3-12岁之间。通过对家长进行面对面采访,研究者收集了大量的信息,其中包括孕期抗生素使用情况、孩子出生后6月内的母乳喂养模式和一些基本情况。

作者也提醒,由于本研究是回顾性、观察性的研究,所以不能得出因果性结论。另外,虽然研究者发现母乳喂养有利于改善产前抗生素暴露对儿童哮喘的影响,但这背后的机制尚不明确,还需要进一步的研究。

原始出处:

Xiaona Huo, Shuyuan Chu, Li Hua, et.al. The effect of breastfeeding on the risk of asthma in high-risk children: a case-control study in Shanghai, China. BMC Pregnancy and Childbirth201818:341

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    2018-08-29 zhangqingzui

    好好学习,感谢

    0

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Aliment Pharmacol Ther:母乳喂养降低克罗恩病及溃疡性结肠炎风险?

包括克罗恩病(CD)和溃疡性结肠炎(UC)在内的炎性肠病(IBD)在全球范围内的发病率不断上升。 IBD的确切原因仍不完全清楚。通常认为IBD由遗传易感性、环境暴露和对益生菌肠道微生物群的免疫反应失调而引起。2017年11月,发表在《Aliment Pharmacol Ther》的一项由美国和澳大利亚科学家进行的系统评价和meta分析,考察了母乳喂养与CD和UC风险之间的相关性。

JEM:母乳喂养或有效防止食物过敏

波士顿儿童医院的一项新研究发现,在怀孕期间食用过敏源食物可以防止其后代食物过敏,采用母乳喂养的话尤其如此。该研究于近日发表在《实验医学》的在线版本上。这是首个表明可以通过母乳防止食物过敏的受控研究,同时也指明了诱导食物耐受的生物学机制。

JAMA Intern Med:30年随访证实6个月以上母乳喂养即可大幅降低母亲糖尿病风险

研究通过纵向生化证据证实,母乳喂养可大大降低母亲的糖尿病风险,持续6个月以上的母乳喂养即可获得最大的糖尿病风险降低收益

JAMA Pediatr:乳喂养更好?能保护新生儿免受感染!

都说母乳喂养好处多多,现在科学家们又找到了证明这一观点的新证据!原来,女性的母乳中含有能够抵抗入侵者(如细菌)的免疫细胞——先天淋巴细胞(innate lymphoid cells,ILCs)。

J EXP MED:母乳如何帮助新生儿对抗食物过敏

现今为止,我们对于母体免疫反应在耐受诱导中的作用还知之甚少。为了研究母体过敏原致敏是否会影响子代对食物过敏的易感性,来自波士顿儿童医院的研究人员利用卵清蛋白(OVA)对表皮敏感的雌性小鼠进行表皮致敏,而后用OVA的表皮致敏和口服来刺激它们的后代。