Clinica Chimica Acta:血清总脂肪酸与2型糖尿病的关系

2020-02-18 Gladiator MedSci原创

2型糖尿病(T2D)是一种与血清游离脂肪酸密切相关典型的代谢性疾病。但尚未见报道血清总脂肪酸(TFAs、游离脂肪酸和酯化脂肪酸)与T2D的关系。

2糖尿病(T2D)是一种与血清游离脂肪酸密切相关典型的代谢性疾病。但尚未见报道血清总脂肪酸(TFAs、游离脂肪酸和酯化脂肪酸)T2D的关系。

研究人员在碱性条件下水解血清酯化脂肪酸,酸化后提取血清TFAs。利用基质辅助激光解吸/电离-傅里叶变换离子回旋共振质谱(MALDI-FTICR MS)8种脂肪酸的校准曲线,同时对1828份血清样本(包括543名对照组、655糖尿病前期患者和630T2D患者)中的14份血清TFAs进行了定量。

相关分析显示,与对照组和糖尿病前期患者相比,T2D患者的血清TFAsTFAs比值在男性和女性中都有很强的相关性。接收者操作特征分析表明,包括空腹血糖,糖基化血红蛋白A1c型,γ-谷氨酰转移酶,甘油三酸酯,C181C203的检测组具有良好的区分糖尿病和T2D的能力,灵敏度为87.0%, 特异性为91.0%,曲线下面积(AUC)为0.96

在本研究中,使用MALDI-FTICR对血清TFAs进行快速、绝对、同时定量,MS. C18:1C20:3与糖尿病前期和T2D显著相关。

原始出处:

Na LiYuming QiuAssociation of serum total fatty acids with type 2 diabetes

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    2020-09-16 windight
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    2020-02-18 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-02-18 飛歌

    学习了很有用不錯

    0