PLoS One:巩膜壁向内塌陷而不是脉络膜增厚,是导致小梁切除手术后低眼压黄斑病变的主要原因!

2018-01-30 cuiguizhong MedSci原创

日本神户神户大学医学研究科眼科的Sakamoto M近日在PLoS One发表了一项重要的工作。作者之前的研究表明,在小梁切除手术(TLE)后,出现低眼压黄斑病变(HM),其视轴长度(AL)比没有低眼压黄斑病的视轴缩短,这表明巩膜壁向内塌陷可能有助于TLE术后HM的发展。然而,作者没有评估脉络膜厚度(CT)的变化,这可能会影响AL的测量。在这篇文章中,作者通过同时测量TLE前后的这些参数,分别在有

日本神户神户大学医学研究科眼科的Sakamoto M近日在PLoS One发表了一项重要的工作。作者之前的研究表明,在小梁切除手术(TLE)后,出现低眼压黄斑病变(HM),其视轴长度(AL)比没有低眼压黄斑病的视轴缩短,这表明巩膜壁向内塌陷可能有助于TLE术后HM的发展。然而,作者没有评估脉络膜厚度(CT)的变化,这可能会影响AL的测量。在这篇文章中,作者通过同时测量TLE前后的这些参数,分别在有无HM的情况下,比较视轴长度和脉络膜厚度变化的幅度和速率。

他们收集了77例在2014年3月至2016年3月期间接受TLE治疗的连续性青光眼患者,总共为77例眼。分别在术前和术后测量眼压(IOP)、中央角膜厚度、角膜曲率、视轴长度和脉络膜厚度,直到术后6个月。在有和没有HM的眼中比较这些生物参数。

结果他们发现患有HM的14名患者具有显着的年轻化。与没有患HM的患者(0.7%)相比,HM患者的眼部视轴长度(AL)显着降低(2.8%)。两组间脉络膜厚度(CT)变化无显着性差异。AL减少与年龄、术后眼压和术前AL有显着的相关性。调整后的逻辑回归分析显示,AL降低率超过2%的患者发生HM的风险增加了11.67(95%可信区间,1.28-106.6; P = 0.03)。

因此,他们认为,视轴长度降低(AL)率超过2%与低眼压黄斑病变(HM)的发生存在显着的相关性。HM眼睛中AL的过度减少不是由脉络膜增厚引起的,而是反映了眼球前后径的减少。巩膜壁向内塌陷导致脉络膜视网膜组织的冗余,最终导致小梁切除手术(TLE)后出现低眼压黄斑病变(HM)。

原文出处:

Sakamoto, M., et al., Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy. PLoS One, 2018. 13(1): p. e0191862.

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    2018-02-01 swallow
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    2018-02-01 muzishouyi
  6. [GetPortalCommentsPageByObjectIdResponse(id=1700536, encodeId=2d041e0053618, content=<a href='/topic/show?id=a959103143df' target=_blank style='color:#2F92EE;'>#黄斑病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103143, encryptionId=a959103143df, topicName=黄斑病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=209430152341, createdName=liuli5089, createdTime=Fri Apr 20 16:26:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687010, encodeId=0523168e01018, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Sat Mar 31 18:26:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790112, encodeId=9d301e9011271, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Jan 31 04:26:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293994, encodeId=95c812939942e, content=<a href='/topic/show?id=6c20e273679' target=_blank style='color:#2F92EE;'>#眼压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72736, encryptionId=6c20e273679, topicName=眼压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83a4244, createdName=swallow, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525121, encodeId=ee871525121ad, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543370, encodeId=396115433e0e6, content=<a href='/topic/show?id=296f319115a' target=_blank style='color:#2F92EE;'>#切除手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31911, encryptionId=296f319115a, topicName=切除手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c013575702, createdName=ms9476844295372110, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283661, encodeId=746128366175, content=日本神户神户大学医学研究科眼科的SakamotoM近日在PLoSOne发表了一项重要的工作., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 30 23:06:45 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283635, encodeId=a00e28363589, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 30 22:31:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1700536, encodeId=2d041e0053618, content=<a href='/topic/show?id=a959103143df' target=_blank style='color:#2F92EE;'>#黄斑病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103143, encryptionId=a959103143df, topicName=黄斑病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=209430152341, createdName=liuli5089, createdTime=Fri Apr 20 16:26:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687010, encodeId=0523168e01018, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Sat Mar 31 18:26:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790112, encodeId=9d301e9011271, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Jan 31 04:26:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293994, encodeId=95c812939942e, content=<a href='/topic/show?id=6c20e273679' target=_blank style='color:#2F92EE;'>#眼压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72736, encryptionId=6c20e273679, topicName=眼压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83a4244, createdName=swallow, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525121, encodeId=ee871525121ad, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543370, encodeId=396115433e0e6, content=<a href='/topic/show?id=296f319115a' target=_blank style='color:#2F92EE;'>#切除手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31911, encryptionId=296f319115a, topicName=切除手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c013575702, createdName=ms9476844295372110, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283661, encodeId=746128366175, content=日本神户神户大学医学研究科眼科的SakamotoM近日在PLoSOne发表了一项重要的工作., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 30 23:06:45 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283635, encodeId=a00e28363589, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 30 22:31:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 有备才能无患

    日本神户神户大学医学研究科眼科的SakamotoM近日在PLoSOne发表了一项重要的工作.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1700536, encodeId=2d041e0053618, content=<a href='/topic/show?id=a959103143df' target=_blank style='color:#2F92EE;'>#黄斑病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103143, encryptionId=a959103143df, topicName=黄斑病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=209430152341, createdName=liuli5089, createdTime=Fri Apr 20 16:26:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687010, encodeId=0523168e01018, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Sat Mar 31 18:26:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790112, encodeId=9d301e9011271, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Jan 31 04:26:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293994, encodeId=95c812939942e, content=<a href='/topic/show?id=6c20e273679' target=_blank style='color:#2F92EE;'>#眼压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72736, encryptionId=6c20e273679, topicName=眼压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83a4244, createdName=swallow, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525121, encodeId=ee871525121ad, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543370, encodeId=396115433e0e6, content=<a href='/topic/show?id=296f319115a' target=_blank style='color:#2F92EE;'>#切除手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31911, encryptionId=296f319115a, topicName=切除手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c013575702, createdName=ms9476844295372110, createdTime=Thu Feb 01 13:26:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283661, encodeId=746128366175, content=日本神户神户大学医学研究科眼科的SakamotoM近日在PLoSOne发表了一项重要的工作., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Jan 30 23:06:45 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283635, encodeId=a00e28363589, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 30 22:31:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 清风拂面

    谢谢分享学习

    0

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