JCC:抗肿瘤坏死因子α在治疗炎症性肠病患者并不增加淋巴瘤发生的风险

2018-10-02 MedSci MedSci原创

目前有些研究报道了抗肿瘤坏死因子α试剂与炎性肠病患者中淋巴瘤发生风险之间的关联。但是,这些研究的结果并不一致。因此,有研究人员进行了一项meta分析进行了相关验证。

背景和目标
目前有些研究报道了抗肿瘤坏死因子α试剂与炎性肠病患者中淋巴瘤发生风险之间的关联。但是,这些研究的结果并不一致。因此,有研究人员进行了一项meta分析进行了相关验证。

方法
研究人员搜索MEDLINE,EMBASE和Cochrane数据库以收集用抗肿瘤坏死因子α试剂治疗炎性肠病患者中淋巴瘤风险的相关研究,并进行荟萃分析以计算汇总发病率比率以及风险比率与抗肿瘤坏死因子α之间的关系。

结果
本项荟萃分析纳入了12项研究,其中包括了285811名实验者。结果显示,使用抗肿瘤坏死因子α药物和未使用抗肿瘤坏死因子α药物组之间淋巴瘤的风险没有显着差异(P= 0.534)。然而,抗肿瘤坏死因子α药物的单药治疗[随机效应:IRR = 1.65,95%CI,1.16-2.35;P= 0.006;随机效应:RR = 1.00,95%CI,0.39-2.59;P= 0.996]或联合治疗[随机效应:IRR = 3.36,95%CI,2.23-5.05;P<0.001;随机效应:RR = 1.90,95%CI,0.66-5.44;P= 0.233]可显着增加淋巴瘤的风险。

结论
炎症性肠病患者中抗肿瘤坏死因子α试剂的暴露与淋巴瘤的高风险无关。联合治疗和抗肿瘤坏死因子α药物单药治疗可显着增加炎症性肠病患者淋巴瘤的风险。

原始出处:

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    2018-12-11 12432a7fm56暂无昵称

    单药治疗是什么意思?

    0

  3. 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    2018-10-06 121832a9m88暂无昵称

    学习了

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=347730, encodeId=5b9c34e7304a, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Oct 03 07:51:03 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-04 millore
  5. 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  6. 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  7. 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  9. 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    2018-10-03 kafei

    学习了谢谢

    0

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目前为止小儿炎症性肠病(IBD)的诊断仍然具有挑战性,针对儿童克罗恩病(CD)和溃疡性结肠炎(UC)之间的鉴别诊断目前还没有很好的办法来实现。而作为未定型IBD(IBDU)患者预测因子的免疫组织化即通过测量肠粘膜中CD30 +淋巴细胞来预测疾病的诊断目前还没有人进行研究。

IBD :Faecalibacterium prausnitzii菌通过制造丁酸盐改善结肠直肠结肠炎

炎症性肠病(IBD)相关的微生态失调的特征在于普鲁氏芽孢杆菌的丧失,而这种细菌的上清液发挥着抗炎的作用。然而,F. prausnitzii菌上清液中的抗炎物质和改善IBD结肠炎的机制尚未得到充分研究。本项研究就此开展了相关的研究。

DDS: 高龄不会对IBD中与健康相关的生活质量产生负面影响

与炎症性肠病(IBD)患者相关的健康相关生活质量(HRQoL)受到许多因素的影响。许多研究评估了各年龄段患者的HRQoL,但很少关注老年人。本项研究的目的是确定高龄(> 65岁)和诊断年龄对IBD患者的影响。

JCC: 戈利木单抗对中度至重度活动性溃疡性结肠炎患者能起到长期缓解

戈利木单抗已经在治疗溃疡性结肠炎中得到广泛应用,因此,本项研究旨在评估中度至重度活动性溃疡性结肠炎患者的皮下注射戈利木单抗维持的安全性和有效性的情况。

JCC : 抗肿瘤坏死因子在影响炎性肠病患者潜在发生结核感染的前瞻性研究

生物疗法彻底改变了免疫介导疾病的治疗方法,特别是炎症性肠病[IBD]和风湿病。然而,生物治疗与潜伏性结核再激活的风险增加有关。生物治疗期间定期监测潜伏性结核感染[LTBI]的重要性目前还没有得到应有的重视。

JCC: 尤特科单抗(Ustekinumab)对中度至重度克罗恩病患者健康相关生活质量的影响

尤特科单抗(ustekinumab)作为一种治疗克罗恩病的新药, 目前对于它的研究还比较匮乏,本项研究旨在研究其对克罗恩病患者健康相关生活质量[HRQOL]的影响。