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Adv Healthc Mater：可注射生物降解热凝胶治疗青光眼

2019-11-25 不详 网络

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具有广泛持续释放和多种功能的先进药物递送系统的开发对于有效减轻与炎症性青光眼有关的眼细胞外基质的降解非常重要。在此，在可注射的可生物降解的热凝胶中胺端基的聚酰胺酰胺树状聚合物的生成对于延长药物释放曲线和有效的抗炎作用非常重要。在第三代（Gx，x = 0、1、3、5）中，第三代G3被证明是最有效的材料，可优化明胶和聚N-异丙基丙烯酰胺的协同作用，并产生具有最高生物降解性的热凝胶耐药性，最佳的药物包封

具有广泛持续释放和多种功能的先进药物递送系统的开发对于有效减轻与炎症性青光眼有关的眼细胞外基质的降解非常重要。在此，在可注射的可生物降解的热凝胶中胺端基的聚酰胺酰胺树状聚合物的生成对于延长药物释放曲线和有效的抗炎作用非常重要。

在第三代（Gx，x = 0、1、3、5）中，第三代G3被证明是最有效的材料，可优化明胶和聚N-异丙基丙烯酰胺的协同作用，并产生具有最高生物降解性的热凝胶耐药性，最佳的药物包封/延长释放性能以及减少炎症分子高表达的最佳能力。基于前房内注射与毛果芸香碱和抗坏血酸共载的热凝胶的药物疗法，由于抗炎活性和长效药物释放（在80天内超过10 µg mL-1的治疗水平），可有效缓解进行性青光眼。热凝胶，可同时抑制炎症并刺激基质胶原和视网膜层粘连蛋白的再生。

这些关于合理设计的可注射生物材料具有强效抗炎作用和受控药物释放的树突作用的这些发现证明了其在进行性青光眼的药物治疗中的巨大前景。

原始出处：

Nguyen DD, Luo LJ, et al., Dendritic Effects of Injectable Biodegradable Thermogels on Pharmacotherapy of Inflammatory Glaucoma-Associated Degradation of Extracellular Matrix. Adv Healthc Mater. 2019 Nov 20:e1900702. doi: 10.1002/adhm.201900702.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1861349, encodeId=88d5186134968, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Aug 20 15:34:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461047, encodeId=593c146104eff, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621825, encodeId=c0811621825c4, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=)]
    2020-08-20 shizhenshan

    #ALT#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1861349, encodeId=88d5186134968, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Aug 20 15:34:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461047, encodeId=593c146104eff, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621825, encodeId=c0811621825c4, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=)]
    2019-11-27 智慧医人

    #凝胶#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1861349, encodeId=88d5186134968, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Aug 20 15:34:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461047, encodeId=593c146104eff, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621825, encodeId=c0811621825c4, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Nov 27 09:34:00 CST 2019, time=2019-11-27, status=1, ipAttribution=)]
    2019-11-27 yyanpro@28cn.c

    #Health#

    0