Am J Transl Res:中药可通过肠细菌肌酸酐分解影响尿毒症大鼠结肠透析

2020-02-27 不详 网络

本研究旨在探讨中药结肠透析对尿毒症大鼠肠道细菌肌酸酐分解的影响。将健康雄性SD大鼠随机分为三组,分别为尿毒症组,假手术组和中药组。在尿毒症组和中药组行5/6肾切除术以建立尿毒症模型,假手术组未进行肾切除术。在十周结束时处死所有大鼠。检查血清肌酐。使用苏木精-伊红染色观察大鼠肾脏的组织病理学变化。通过实时荧光定量PCR(16S RNA)定量测定肠道中双歧杆菌,乳酸杆菌和大肠杆菌的数量。结果显示,与假

本研究旨在探讨中药结肠透析对尿毒症大鼠肠道细菌肌酸酐分解的影响。

将健康雄性SD大鼠随机分为三组,分别为尿毒症组,假手术组和中药组。在尿毒症组和中药组行5/6肾切除术以建立尿毒症模型,假手术组未进行肾切除术。在十周结束时处死所有大鼠。检查血清肌酐。使用苏木精-伊红染色观察大鼠肾脏的组织病理学变化。通过实时荧光定量PCR(16S RNA)定量测定肠道中双歧杆菌,乳酸杆菌和大肠杆菌的数量。

结果显示,与假手术组相比,空肠中大肠杆菌的数量明显增加,而回肠中双歧杆菌和乳酸杆菌的数量减少。结肠中双歧杆菌和乳杆菌的数目减少,而大肠杆菌增加。

综上所述,该研究结果表明,中药可通过肠细菌肌酸酐分解影响尿毒症大鼠结肠透析。

原始出处:

Haidong He, Meilin Shen, et al., Influence of colonic dialysis using Chinese medicine on creatinine decomposition by intestinal bacteria in uremia rats. Am J Transl Res. 2019; 11(10): 6577–6584.

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    2020-08-27 bsmagic9140
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    2020-02-29 tcm99hq