Diabetes Care:肥胖对多囊卵巢综合征患者2型糖尿病发病率的影响

2019-02-03 xing.T MedSci原创

由此可见,PCOS患者发生2型糖尿病的风险增加,无论年龄和BMI如何。随着肥胖的增加,2型糖尿病的发病率显著增加;然而,PCOS增加了体瘦女性的相对风险。基于总体中度绝对临床风险,指南建议所有PCOS患者每2-3年接受2型糖尿病筛查,无论BMI分类和年龄范围,其频率受其它2型糖尿病危险因素的影响。

多囊卵巢综合征(PCOS)与2型糖尿病之间关系的性质仍不清楚。很少有研究旨在阐明这种与纵向人群为基础的群体中独立于肥胖的关系。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员使用了澳大利亚妇女健康纵向研究(ALSWH)(2000-2015)数据库,通过人际时间和生存分析,估计了18-42岁女性全国发病率和2型糖尿病预测因子。

在1919人每年(PYs)的随访中,186名女性患上了2型糖尿病。PCOS患者和对照受试者的发病率分别为4.19/1000和1.02/1000PY(P<0.001)。在健康体重、超重和肥胖女性的亚组分析中,2型糖尿病的发病率分别为3.21、4.67和8.80;而相比于年龄匹配的对照受试者,PCOS的发病率比率分别为4.68、3.52和2.36(P<0.005)。PCOS是整个队列中2型糖尿病最强烈的预测因素之一(风险比为3.23,95%CI为2.07-5.05,P<0.001),调整了BMI、教育程度、居住地区和2型糖尿病家族史。

由此可见,PCOS患者发生2型糖尿病的风险增加,无论年龄和BMI如何。随着肥胖的增加,2型糖尿病的发病率显著增加;然而,PCOS增加了体瘦女性的相对风险。基于总体中度绝对临床风险,指南建议所有PCOS患者每2-3年接受2型糖尿病筛查,无论BMI分类和年龄范围,其频率受其它2型糖尿病危险因素的影响。

原始出处:

Nadira S. Kakoly,et al.The Impact of Obesity on the Incidence of Type 2 Diabetes Among Women With Polycystic Ovary Syndrome.Diabetes Care.2019.https://doi.org/10.2337/dc18-1738

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    2019-02-04 misszhang

    谢谢MedSci提供最新的资讯

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由此可见,该研究中表明服用的益生菌不能预防超重和肥胖孕妇的GDM。

不是肥胖,原来是肝囊肿!

肝囊肿是比较常见的肝良性疾病,临床多见的是先天性肝囊肿。先天性肝囊肿生长缓慢,小的囊肿不引起任何症状,多系超声、CT等影像学检查或其他腹部手术中发现。囊肿增大到一定程度,则可产生压迫症状。