Asian Pac J Allergy Immunol:青葱的抗过敏活性和治疗过敏性鼻炎效果研究

2019-08-28 AlexYang MedSci原创

洋葱具有抗过敏活性,而青葱缺乏相关证据。最近,有研究人员确定了是否青葱具有与洋葱相似的抗过敏活性以及过敏性鼻炎的治疗效果。研究是一个临床、随机、双盲和安慰剂对照试验。研究包括了16名AR患者并随机均分成2个小组,对照组和试验组。研究发现,青葱提取物在200μg/mL时对β-六氨基酶的平均抑制率为97%,而相同浓度下洋葱提取物为73%。洋葱和青葱的HPLC色谱图(λ=290nm)表明了这2种植物的槲

洋葱具有抗过敏活性,而青葱缺乏相关证据。

最近,有研究人员确定了是否青葱具有与洋葱相似的抗过敏活性以及过敏性鼻炎的治疗效果。研究是一个临床、随机、双盲和安慰剂对照试验。研究包括了16名AR患者并随机均分成2个小组,对照组和试验组。研究发现,青葱提取物在200μg/mL时对β-六氨基酶的平均抑制率为97%,而相同浓度下洋葱提取物为73%。洋葱和青葱的HPLC色谱图(λ=290nm)表明了这2种植物的槲皮素化合物基本一致,比如槲皮素3,4'-二糖苷、槲皮素4'-糖苷和槲皮素。在4周的治疗后,青葱组中62.5%的患者和对照组中37.5%的患者表现出了治疗后VAS改善。TNSS在2个小组中均显著减少,而没有差异(P=0.18)。TOSS只在青葱组中具有显著的改善(P=0.01)。青葱的副作用事件与安慰剂组没有什么不同。

最后,研究人员指出,青葱具有抗过敏活性并且与洋葱的槲皮素化合物相似。青葱与西替利嗪组合使用可以改善总的AR症状,且效果比单独使用西替利嗪更好。

原始出处:

Arpornchayanon W, Klinprung S, Chansakaow S et al. Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis. Asian Pac J Allergy Immunol. 18 Aug 2019

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    2019-09-10 智慧医人
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    2019-08-30 膀胱癌
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    2019-08-28 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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