Gastroenterology:年轻化结直肠癌发病及生存率的种族差异研究

2019-03-14 MedSci MedSci原创

研究者发现,年轻结肠癌患者的生存率存在种族差异,但直肠癌则没有。近年来年轻结肠癌患者数量增加主要是由于直肠癌导致的,在白种人中尤其突出

直肠癌(CRC)发病年轻化越来越受到人们的关注,近日研究人员比较了50岁以下成年人群在两个时间段内的CRC发病率和相对存活率,以考察早发性CRC的种族差异。

研究考察了1992-1996年以及2010-2014年间,20-49岁的白人与黑人CRC发病率,通过与健康人群相比较计算相对存活率。

从1992-1996年到2010-2014年,白人CRC发病率从每10万人7.5例增加到11.0例,黑人发病率从每10万人11.7例增加到12.7例。与黑人相比(从每10万人3.4例增至4.0例),白人的直肠癌发病率上升幅度更大(从每10万人2.7例增至4.5例),导致在2010-2014年期间,黑人和白人的直肠癌发病率相似。与白人相比,黑人近端结肠癌的相对存活率增加幅度较小,但直肠癌的存活率增加更大(由55.3%上升至70.8%)。

研究者发现,年轻结肠癌患者的生存率存在种族差异,但直肠癌则没有。近年来年轻结肠癌患者数量增加主要是由于直肠癌导致的,在白种人中尤其突出。

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    2019-07-31 许安
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