Anaesthesia:常熬夜?睡眠不足或引发多种疾病

2019-02-12 佚名 Wiley威立

《Anaesthesia 》上一项研究将睡眠不足与DNA损伤联系在了一起。研究人员在不同时间点提取了49名健康的全职医生的血液并进行分析,结果显示被要求在现场通宵工作的医生比未通宵工作的医生DNA修复基因表达度更低,DNA断裂更多。这些需要通宵工作医生仅仅经历了一个晚上的睡眠剥夺,体内DNA的修复基因表达度便有所减少,受损DNA也随之增加!

《Anaesthesia 》上一项研究将睡眠不足与DNA损伤联系在了一起。研究人员在不同时间点提取了49名健康的全职医生的血液并进行分析,结果显示被要求在现场通宵工作的医生比未通宵工作的医生DNA修复基因表达度更低,DNA断裂更多。这些需要通宵工作医生仅仅经历了一个晚上的睡眠剥夺,体内DNA的修复基因表达度便有所减少,受损DNA也随之增加!

此课题虽仍需深入研究,但是这种DNA损伤有助于解释由睡眠不足导致的癌症、血管、代谢和神经退行性疾病风险增加的现象。

作者指出,尽管这项研究还处于初级阶段,但从研究结果来看,很明显,哪怕是一晚的睡眠不足也会引发DNA损伤,这有可能是导致慢性疾病发展的原因。

《Anaesthesia 》期刊主编 Klein 提出“麻醉师(和其他卫生专业人员)的工作需要随叫随到且经常值夜班,因此工作时间在日夜之间切换是常有的事。这项开创性研究的意义就在于能够引导后来者在此基础上,通过评估DNA断裂程度来研究人们改变工作方式和其他干扰因素带来的影响。”

原始出处:
V. Cheung, V. M. Yuen,  G. T. C. Wong, et al. The effect of sleep deprivation and disruption on DNA damage and health of doctors. Anaesthesia. Jan 2019.


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    2019-08-28 AspirantSuo
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    2019-02-14 skhzy
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    2019-02-14 一天没事干

    很好的学习机会

    0

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    2019-02-13 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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