Eur Heart J:无卒中房颤患者的痴呆风险

2019-06-20 xing.T MedSci原创

由此可见,AF与痴呆风险增加有关,与老年人群的卒中无关。口服抗凝剂的使用与痴呆的发生率降低有关。

房颤(AF)通常被认为是痴呆的危险因素,尽管纵向研究评估AF与痴呆之间的关联已得出不一致的结果。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,该研究旨在通过纵向、社区和无卒中老年人群确定房颤对痴呆发病风险的影响。

2005年至2012年,研究人员通过韩国国家健康保险服务-高级队列中的262611名年龄≥60岁的痴呆和无卒中参与者评估了事件性AF与痴呆事件发生之间得的关系。

在随访期为1629903人次每年(0.64%/年)的10435名参与者中观察到事件AF。在观察期间,事件AF和倾向评分匹配的无AF组的痴呆发病率分别为4.1和2.7/100人每年。调整后,即使在卒中评估(1.27,95%CI为1.18-1.37)后,罹患痴呆的风险显著增加,风险比(HR)为1.52 [95%置信区间(CI)为1.43-1.63] 。事件AF增加了阿尔茨海默氏症(HR为1.31,95%CI为1.20-1.43)和血管性痴呆(HR为2.11,95%CI为1.85-2.41)的风险。在AF患者中,口服抗凝剂使用与痴呆发展的预防作用相关(HR为0.61,95%CI为0.54-0.68),并且CHA2DS2-VASc评分的增加与痴呆的高风险相关。

由此可见,AF与痴呆风险增加有关,与老年人群的卒中无关。口服抗凝剂的使用与痴呆的发生率降低有关。 

原始出处:


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    2019-10-10 123de590m20暂无昵称

    很好

    0

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    2019-07-20 敢心

    学会与房颤和谐共处十分重要,不一定非要花费大力气去治愈。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=373757, encodeId=8c8a3e3757ba, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210924/4ea70a3dcb1c45f5b79c619208e50ed3/e5680d86f38c4e86b9c69a138ea6aaa2.jpg, createdBy=61ad2443812, createdName=123de590m20暂无昵称, createdTime=Thu Oct 10 23:56:02 CST 2019, time=2019-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369965, encodeId=32ad369965cc, content=学会与房颤和谐共处十分重要,不一定非要花费大力气去治愈。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Sat Jul 20 04:51:24 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368264, encodeId=b4e9368264cc, content=抗凝重要吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Mon Jun 24 09:34:39 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368211, encodeId=3e343682118c, content=房颤专科门诊很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Sun Jun 23 14:39:37 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316728, encodeId=3d2e1316e2850, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357212, encodeId=0512135e212ee, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563109, encodeId=31f71563109d3, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614513, encodeId=0f2516145138d, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026389, encodeId=c1ed10263894b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Jun 20 11:36:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048542, encodeId=5f5f104854204, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 20 11:36:00 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
    2019-06-24 敢心

    抗凝重要吧

    0

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    2019-06-23 敢心

    房颤专科门诊很重要

    0

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    2019-06-21 zhaojie88
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    2019-06-21 slcumt
  8. [GetPortalCommentsPageByObjectIdResponse(id=373757, encodeId=8c8a3e3757ba, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210924/4ea70a3dcb1c45f5b79c619208e50ed3/e5680d86f38c4e86b9c69a138ea6aaa2.jpg, createdBy=61ad2443812, createdName=123de590m20暂无昵称, createdTime=Thu Oct 10 23:56:02 CST 2019, time=2019-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369965, encodeId=32ad369965cc, content=学会与房颤和谐共处十分重要,不一定非要花费大力气去治愈。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Sat Jul 20 04:51:24 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368264, encodeId=b4e9368264cc, content=抗凝重要吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Mon Jun 24 09:34:39 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368211, encodeId=3e343682118c, content=房颤专科门诊很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67182624830, createdName=敢心, createdTime=Sun Jun 23 14:39:37 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316728, encodeId=3d2e1316e2850, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357212, encodeId=0512135e212ee, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563109, encodeId=31f71563109d3, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614513, encodeId=0f2516145138d, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Jun 21 23:36:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026389, encodeId=c1ed10263894b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Jun 20 11:36:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048542, encodeId=5f5f104854204, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 20 11:36:00 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
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    2019-06-20 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2019-06-20 junJUN

    老年人痴呆何药可用??

    0