Chest:阿司匹林与肺气肿样肺脏进展之间的相关性分析!

2017-12-14 xing.T MedSci原创

由此可见,定期服用阿司匹林与10年期间肺气肿进展率降低了50%以上相关。进一步研究阿司匹林和血小板在肺气肿中的作用是很有必要的。

血小板活化可降低肺部微血管血流并促进炎症反应,这与慢性阻塞性肺疾病以及肺气肿的发病有关。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员假设经常使用阿司匹林,抑制血小板,会减慢肺气肿样肺脏的进展,减缓肺功能下降。

动脉粥样硬化的多民族研究(MESA研究)在2000年至2002年期间招募了45-84岁无临床血管疾病的参与者。MESA中肺脏研究评估了肺气肿样肺脏的百分比。常规服用阿司匹林定义为每周服用3天或更多天数。研究人员采用调整了人口、人体测量学、吸烟、高血压、ACEI或ARB服用情况、C-反应蛋白、神经鞘磷脂和扫描因素后的混合效应模型进行分析。

基线时,4257名受试者的平均年龄为61±10岁,54%为吸烟者,22%的受试者常规服用阿司匹林。10年内平均肺气肿百分比增加了0.60个百分点(95%可信区间为0.35-0.94)。与未定期服用阿司匹林的受试者相比,定期服用阿司匹林的受试者肺气肿百分比进展较慢(充分调整模型为:-0.34%/10年,95%可信区间为-0.60至-0.08;P=0.01)。在吸烟者、服用剂量为81mg和300-325mg的受试者以及那些气流受限的剂量更大的受试者中结果类似。研究人员发现服用阿司匹林与肺功能的变化之间不存在相关性。

由此可见,定期服用阿司匹林与10年期间肺气肿进展率降低了50%以上相关。进一步研究阿司匹林和血小板在肺气肿中的作用是很有必要的。

原始出处:

Carrie P. Aaron,et al. A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung on CT: The MESA Lung Study.chest.2017. http://journal.chestnet.org/article/S0012-3692(17)33210-5/fulltext

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    2018-11-09 Smile2680
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    2017-12-16 smartxiuxiu

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2050981, encodeId=758a205098157, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Dec 16 03:46:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837404, encodeId=a22c183e404a3, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Jul 29 23:46:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929448, encodeId=627b1929448d9, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Nov 09 18:46:00 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523572, encodeId=d5e215235e225, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Sat Dec 16 14:46:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269814, encodeId=ad082698144f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Dec 16 09:20:38 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269469, encodeId=a1cf26946968, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Dec 15 01:11:21 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269466, encodeId=93d52694668e, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Dec 15 01:02:40 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269458, encodeId=7b70269458fd, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Fri Dec 15 00:05:23 CST 2017, time=2017-12-15, status=1, ipAttribution=)]
    2017-12-15 jihuaijun1112

    学习学习学习

    0

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    2017-12-15 飛歌

    学习了很有用不错

    0

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    2017-12-15 txqjm

    谢谢了.学习

    0

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新研究显示,将阿司匹林添加到一些现有的抗癌药物中,可以提高其对抗治疗肿瘤的效力。

全世界只有这两个可称为“神药”

近日,一年卖出7.5亿的洗脑“神药”莎普爱思被推到风口浪尖。其实,在我们生活中,真的有一些当之无愧的“神药”。

Gastroenterology:阿司匹林不能降低一般人群的胰腺癌风险

研究认为,规律的使用阿司匹林以及其他非甾体抗炎药不能降低一般人群的胰腺癌风险,仅糖尿病患者可能从阿司匹林预防中获益,但该结果需要进一步研究确证

Neurology:低剂量阿司匹林不增加颅内出血风险,反而降低SAH风险

低剂量阿司匹林广泛应用于缺血性血管事件的二级预防,甚至用于一级预防。随机对照试验或随机对照试验联合队列研究的meta分析把阿司匹林和颅内出血风险增加联系起来,发现二者未达到统计学意义或处于边缘状态。观察性研究的结果更是模棱两可,甚至有研究认为长期服用阿司匹林能够降低蛛网膜出血的风险。

Gastroenterology:低剂量阿司匹林不能降低食管癌或胃癌患者死亡风险

研究认为低剂量的阿司匹林不能降低食管癌或胃癌患者的死亡风险