JACC:伴糖尿病冠心病患者PCI和CABG治疗预后无明显差异

2019-04-11 不详 MedSci原创

EXCEL临床随机对照试验结果显示对于左主干冠脉(LMCAD)病变患者,冠脉搭桥(CABG)和经皮冠脉介入治疗(PCI)的三年主要终点事件发生率相似,然而这对于高风险患者如伴有糖尿病的患者是否有同样的结果尚不清楚。本研究纳入分析了1905例LMCAD病变患者,其中554名伴有糖尿病,随机1:1分至PCI支架植入组和CABG组,并根据是否有糖尿病进行分层,主要终点事件是3年全因死亡、卒中和心梗的复合

EXCEL临床随机对照试验结果显示对于左主干冠脉(LMCAD)病变患者,冠脉搭桥(CABG)和经皮冠脉介入治疗(PCI)的三年主要终点事件发生率相似,然而这对于高风险患者如伴有糖尿病的患者是否有同样的结果尚不清楚。

本研究纳入分析了1905例LMCAD病变患者,其中554名伴有糖尿病,随机1:1分至PCI支架植入组和CABG组,并根据是否有糖尿病进行分层,主要终点事件是3年全因死亡、卒中和心梗的复合事件。分析结果显示,与非糖尿病患者相比,伴有糖尿病患者的主要终点事件发生率明显更高(20.0% vs. 12.9%; p < 0.001),在伴有糖尿病患者和无糖尿病患者中,PCI组和CABG组的主要终点事件发生率无明显差异。3年的全因死亡率在PCI组和CABG组中分别是13.6%和9.0%(p=0.046),糖尿病状态和全因死亡治疗之间没有明显的相互作用(p = 0.22)。

研究结果显示,EXCEL临床随机对照试验的结果在伴有糖尿病患者和无糖尿病患者中结果是一致的,PCI和CABG的主要终点事件率无明显差异。

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    2019-07-21 hbwxf
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    2019-04-11 misszhang

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