Diabetes Care:1型糖尿病老年人的严重低血糖症和认知功能

2019-12-29 xing.T MedSci原创

由此可见,在T1D老年人中,近期SH和终生SH与较差的认知能力有关。最近的SH与整体认知能力下降有关。这些结果表明SH对老年T1D患者的大脑健康具有不良影响,并突出了预防SH的重要性。

在1型糖尿病(T1D)患儿中,严重的低血糖症(SH)与较差的认知能力相关,但尚不清楚SH与晚期生命中的认知功能之间的相关性。鉴于T1D患者的预期寿命不断增加,因此了解SH在大脑健康中的作用至关重要。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员评估了糖尿病长寿(SOLID)研究中718名T1D成年人SH与认知功能之间的关系。受试者自我报告了最近的(过去12个月)SH和终身S需要住院/急诊就诊的SH史。研究人员评估了整体和特定领域的认知水平(语言、执行功能、情景记忆和简单注意),并分别通过线性和Logistic回归模型评估了SH与认知功能和认知障碍之间的关联。

32%的参与者(平均年龄为67.2岁)报告了最近的SH,而50%的患者报告了终生SH。与没有SH的受试者相比,最近有SH病史的受试者整体认知得分要低得多。特定领域的分析显示,最近的SH暴露下,语言、执行功能和情节记忆得分显著降低,而在终身SH暴露下,执行功能显著降低。最近的SH与整体认知能力受损(比值比[OR]为3.22,95%CI为1.30-7.94)和语言领域的认知障碍(OR为3.15,95%CI为1.19-8.29)相关。

由此可见,在T1D老年人中,近期SH和终生SH与较差的认知能力有关。最近的SH与整体认知能力下降有关。这些结果表明SH对老年T1D患者的大脑健康具有不良影响,并突出了预防SH的重要性。

原始出处:

Mary E. Lacy.et al.Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID).Diabetes Care.2019.https://care.diabetesjournals.org/content/early/2019/12/26/dc19-0906

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    2019-12-29 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2019-12-29 184****9840

    学习了,谢谢分享

    0

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由此可见,Lp(a)是1型糖尿病患者大血管疾病、白蛋白尿和钙化主动脉瓣膜疾病的重要危险因素。1型糖尿病患者的代谢控制不良与Lp(a)水平升高有关。

Diabetes Care:1型糖尿病年轻人自杀风险评估

由此可见,该研究的结果对具有自杀和死亡观念的1型糖尿病青壮年的行为和认知提供了初步了解。在常规的1型糖尿病门诊就诊期间,开展全面的自杀风险评估和安全计划是可行的。