JACC:高密度脂蛋白相关评分可预测冠心病的发生和死亡

2019-05-03 不详 MedSci原创

循环血中的脂蛋白浓度与冠心病的发病风险呈强相关。本研究的目的旨在高密度脂蛋白(HDL)体学评分(pCAD)对冠心病诊断和预后的影响。本研究对 CASABLANCA临床研究中的943名无心梗冠脉造影患者进行了HDL相关脂蛋白apoA1, apoC-1, apoC-2, apoC-3和apoC-4进行了检测,经过平均4年时间的随访,有587名患者出现了冠脉梗阻,pCAD评分与梗阻性冠心病的发生呈相关性

循环血中的脂蛋白浓度与冠心病的发病风险呈强相关。本研究的目的旨在高密度脂蛋白(HDL)体学评分(pCAD)对冠心病诊断和预后的影响。

本研究对 CASABLANCA临床研究中的943名无心梗冠脉造影患者进行了HDL相关脂蛋白apoA1, apoC-1, apoC-2, apoC-3和apoC-4进行了检测,经过平均4年时间的随访,有587名患者出现了冠脉梗阻,pCAD评分与梗阻性冠心病的发生呈相关性(OR:1.39; 95% [CI]: 1.14-1.69; p < 0.001),且独立于传统血管危险因素。另外,pCAD评分虽然不和所有个体的血管死亡相关,但是与梗阻性冠心病患者的死亡率相关(HR:1.48; 95% CI: 1.07-2.05; p = 0.019)。

研究结果显示,一种基于高密度脂蛋白相关的评分与冠心病的发生呈独立相关性,且与预测冠心病患者死亡风险。

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    2019-11-16 wxl882001

    了解一下

    0

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    2020-01-13 hbwxf
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    2019-09-20 wxl882001

    学习一下

    0

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    2019-08-02 wxl882001

    了解一下

    0

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    2019-05-06 天地飞扬

    学习,谢谢分享!

    0

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    2019-05-06 苏小雨

    学习了,不错

    0

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    2019-05-05 docwu2019
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