Eur Respir J:原发性自发性气胸的复发率

2018-09-06 xing.T MedSci原创

由此可见,该系统评价显示PSP复发率为32%,第一年风险最大。女性为与较高的风险相关,提示可能存在性别特异性病理生理学机制。

原发性自发性气胸(PSP)复发率在已发表的文献中差异很大,有限的数据描述了影响复发的因素。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,该系统评价的目的是明确PSP复发率的估计值并描述影响复发的危险因素。

研究人员对所有报告了PSP复发的研究进行了系统评价,并进行电子检索以确定随机试验和观察性研究的英语文献。研究人群为患有PSP的成年人,他们接受了保守治疗、胸膜穿刺或胸腔引流。感兴趣的结局为PSP复发。研究人员筛选了文献,并由两名评审员从符合条件的研究中提取数据。

在检索出的3607项研究中,有29项符合纳入标准,包含了13548名患者。合并的1年和总体复发率分别为29.0%(95%CI为20.9-37.0%)和32.1%(95%CI为27.0-37.2%)。女性与复发率增加有关(OR为3.03,95%CI为1.24-7.41),而戒烟与风险降低4倍有关(OR为0.26,95%CI为0.10-0.63)。随机效应荟萃分析的I2为94%(p<0.0001),反映了研究之间的高度异质性。

由此可见,该系统评价显示PSP复发率为32%,第一年风险最大。女性为与较高的风险相关,提示可能存在性别特异性病理生理学机制。

原始出处:

Steven P. Walker,et al. Recurrence rates in primary spontaneous pneumothorax: a systematic review and meta-analysis. Eur Respir J. 2018. http://erj.ersjournals.com/content/52/3/1800864

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    2018-09-08 sodoo