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Dent Mater J：羟基磷灰石复合镁纤维材料的骨诱导潜力：一项体内和体外研究

2019-07-21 lishiting MedSci原创

HAf骨诱导
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尽管羟基磷灰石纤维(HAf)作为合成骨成分的替代品已得到充分肯定，但材料如果具有更快的促进骨再生能力将会更好。因此，这篇研究的目的是为了评估HAf 与镁复合(Mg-HAf)后对骨再生的影响。

尽管羟基磷灰石纤维(HAf)作为合成骨成分的替代品已得到充分肯定，但材料如果具有更快的促进骨再生能力将会更好。因此，这篇研究的目的是为了评估HAf 与镁复合(Mg-HAf)后对骨再生的影响。

体外结果显示，Mg-HAf培养下的骨髓细胞成骨分化相关基因表达水平明显高于单独培养于HAf的细胞。此外，研究还评估了仅使用HAf(对照)或5.7 mol% Mg-HAf对Japanese white rabbits颅骨的影响。Micro-CT和组织学结果显示，对照和Mg-HAf组之间存在显著性差异。在4和8周，Mg-HAf组新骨形成的骨量和比例均明显高于对照组(p<0.05)；并且Mg-HAf组新形成的骨组织比对照组更加成熟。

结论：这些结果表明，Mg-HAf能够增强成骨分化相关基因的表达并且能够快速促进骨形成和成熟。

原始出处：

Kozuma W， Kon K， et al. Osteoconductive potential of a hydroxyapatite fiber material with magnesium： In vitro and in vivo studies. Dent Mater J. 2019 Jun 29. doi： 10.4012/dmj.2018-333.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1804494, encodeId=0404180449432, content=<a href='/topic/show?id=2271e7245ac' target=_blank style='color:#2F92EE;'>#纤维材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77245, encryptionId=2271e7245ac, topicName=纤维材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Thu Jan 16 16:25:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055355, encodeId=2da72055355c3, content=<a href='/topic/show?id=d0b7101851ee' target=_blank style='color:#2F92EE;'>#骨诱导#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101851, encryptionId=d0b7101851ee, topicName=骨诱导)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Thu Oct 10 15:25:00 CST 2019, time=2019-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370146, encodeId=3baa3e014649, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jul 23 08:01:05 CST 2019, time=2019-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622169, encodeId=333a1622169b7, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Jul 22 22:25:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370041, encodeId=bbdf3e00418e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Jul 21 09:08:05 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370040, encodeId=18cd3e00409f, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sun Jul 21 09:07:01 CST 2019, time=2019-07-21, status=1, ipAttribution=)]
    2020-01-16 jiangjun073

    #纤维材料#

    0

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    2019-10-10 12498fa0m11暂无昵称

    #骨诱导#

    0

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    2019-07-23 1ddf0692m34(暂无匿称)

    学习了，谢谢分享

    0

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    2019-07-22 爆笑小医

    #羟基磷灰石#

    0

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    2019-07-21 龙胆草

    学习谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1804494, encodeId=0404180449432, content=<a href='/topic/show?id=2271e7245ac' target=_blank style='color:#2F92EE;'>#纤维材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77245, encryptionId=2271e7245ac, topicName=纤维材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Thu Jan 16 16:25:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055355, encodeId=2da72055355c3, content=<a href='/topic/show?id=d0b7101851ee' target=_blank style='color:#2F92EE;'>#骨诱导#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101851, encryptionId=d0b7101851ee, topicName=骨诱导)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Thu Oct 10 15:25:00 CST 2019, time=2019-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370146, encodeId=3baa3e014649, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jul 23 08:01:05 CST 2019, time=2019-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622169, encodeId=333a1622169b7, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Jul 22 22:25:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370041, encodeId=bbdf3e00418e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Jul 21 09:08:05 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370040, encodeId=18cd3e00409f, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sun Jul 21 09:07:01 CST 2019, time=2019-07-21, status=1, ipAttribution=)]
    2019-07-21 orangesking

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