BMJ:妊娠期补充鱼油对儿女骨骼、肌肉和脂肪质量的影响

2018-09-05 xing.T MedSci原创

由此可见,从妊娠第24周开始补充鱼油导致0-6岁的子女BMI较高,但6岁时肥胖风险并未增加。补充鱼油的儿童6岁时身体成分的特征在于肌肉、骨骼和脂肪质量的成比例增加,这表明n-3 LCPUFA具有生长刺激的作用。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在评估妊娠期补充n-3长链多不饱和脂肪酸(n-3 LCPUFA)对子女人体测量学指标和身体成分的影响。

该研究为双盲、随机对照试验,以哥本哈根儿童哮喘前瞻性研究2010年队列为基础,参与者为736名孕妇及其子女。干预措施为从妊娠24周到出生后1周每天补充n-3 LCPUFA(鱼油)或对照剂(橄榄油)。该研究的主要结局指标为双能量X射线吸收测定的身体成分、身高/体长、体重、头部和腰部测量指标(n-3 LCPUFA试验的所有预先指定的次要终点;该试验的主要结局为持续性喘息/哮喘)。

与对照组相比,鱼油补充组0-6岁患者的平均体重指数(BMI)z评分有所增加(0.14(95%置信区间为0.04-0.23); P=0.006)。在6岁时,补充鱼油与较高的BMI z评分(0.19(0.06-0.32);P=0.004)、较高的体重/身高比(3.48(0.38-6.57)g/cm; P=0.03)以及较大腰围(0.6(0.0-1.2)cm; P=0.04)相关,但使用国际肥胖特别工作组等级,肥胖儿童比例不高。 6岁时双能量X射线吸收扫描显示补充鱼油与对照组相比总体质量更高(395.4(86.6-704.3)g; P=0.01),由更高的肌肉重量(280.7(98.9-462.4))g; P=0.002)、骨矿物质含量(10.3(2.3-18.1)g; P = 0.01)以及更高的无显著差异脂肪质量(116.3(-92.9-325.5)g; P=0.28)所解释,但总体脂肪或肌肉治疗百分比没有差异。

由此可见,从妊娠第24周开始补充鱼油导致0-6岁的子女BMI较高,但6岁时肥胖风险并未增加。补充鱼油的儿童6岁时身体成分的特征在于肌肉、骨骼和脂肪质量的成比例增加,这表明n-3 LCPUFA具有生长刺激的作用。

原始出处:

Rebecca Kofod Vinding, et al. Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.BMJ 2018; https://www.bmj.com/content/362/bmj.k3312

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1812725, encodeId=91911812e2572, content=<a href='/topic/show?id=44329015031' target=_blank style='color:#2F92EE;'>#补充鱼油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90150, encryptionId=44329015031, topicName=补充鱼油)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Feb 18 14:31:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848588, encodeId=0072184858845, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jul 05 04:31:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251147, encodeId=5c4a125114e7b, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Sep 07 10:31:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342944, encodeId=83543429442c, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Sep 05 22:24:49 CST 2018, time=2018-09-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1812725, encodeId=91911812e2572, content=<a href='/topic/show?id=44329015031' target=_blank style='color:#2F92EE;'>#补充鱼油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90150, encryptionId=44329015031, topicName=补充鱼油)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Feb 18 14:31:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848588, encodeId=0072184858845, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jul 05 04:31:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251147, encodeId=5c4a125114e7b, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Sep 07 10:31:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342944, encodeId=83543429442c, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Sep 05 22:24:49 CST 2018, time=2018-09-05, status=1, ipAttribution=)]
    2019-07-05 gaoxiaoe
  3. [GetPortalCommentsPageByObjectIdResponse(id=1812725, encodeId=91911812e2572, content=<a href='/topic/show?id=44329015031' target=_blank style='color:#2F92EE;'>#补充鱼油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90150, encryptionId=44329015031, topicName=补充鱼油)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Feb 18 14:31:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848588, encodeId=0072184858845, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jul 05 04:31:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251147, encodeId=5c4a125114e7b, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Sep 07 10:31:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342944, encodeId=83543429442c, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Sep 05 22:24:49 CST 2018, time=2018-09-05, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1812725, encodeId=91911812e2572, content=<a href='/topic/show?id=44329015031' target=_blank style='color:#2F92EE;'>#补充鱼油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90150, encryptionId=44329015031, topicName=补充鱼油)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Feb 18 14:31:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848588, encodeId=0072184858845, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jul 05 04:31:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251147, encodeId=5c4a125114e7b, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Sep 07 10:31:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342944, encodeId=83543429442c, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Sep 05 22:24:49 CST 2018, time=2018-09-05, status=1, ipAttribution=)]
    2018-09-05 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

相关资讯

Hypertension:线粒体功能异常和活性氧均参与介导妊高症的病理过程

胎盘缺血被认为是子娴前期发展的初始事件。线粒体功能异常会导致产生活性氧(ROS)和氧化应激,线粒体ROS是否在子娴前期病理过程中发挥作用,尚无人对此进行研究。Venkata Ramana Vaka等研究人员在子宫低灌注压(RUPP)的子娴前期大鼠模型中研究胎盘缺血线粒体介导的氧化应激的影响,同时研究线粒体ROS是否在胎盘缺血导致高血压的过程中发挥作用。大鼠孕14天时,予以行RUPP术。孕19天时,

全力攻坚!为了拯救妊娠合并肺动脉高压母子生命

今年年初,我院产科主任马锦琪在专家门诊接诊了这位特殊的孕妇,她患有先心房缺和重度肺动脉高压(112mmHg)。

Semin Arthritis Rheu:抗风湿药物在备孕男性中的安全性

这些结果进一步确认了很多DMARDs在备孕男性中的安全性。

Front Cell Neurosci:妊娠中期接触七氟醚对幼鼠学习和记忆的影响:母体锻炼的有益作用

胎儿接触全身麻醉药物可能会有严重的神经认知风险,但是减轻这些有害影响的方法仍不清楚。因此,我们开始评估在大鼠怀孕期间单次或重复接触七氟醚是否会引发大鼠后代的长期认知障碍。由于怀孕期间的母体锻炼已经证明可以改善后代的认知能力,我们假设怀孕期间的母体通过跑步机锻炼可以预防由七氟醚-诱发的神经毒性。

Obstet Gynecol:昂丹司琼治疗妊娠恶心呕吐与特定出生缺陷风险之间的关系

由此可见,用于治疗妊娠恶心和呕吐的昂丹司琼使用率增加至了13%。 对于所研究的大多数特定出生缺陷,与未治疗相比,妊娠早期使用昂丹司琼治疗恶心和呕吐的风险没有增加,尽管其与腭裂和肾发育不全-发育不良的适度关联值得进一步研究。

J Rheumatol:系统性红斑狼疮女性患者的孕前心血管健康和妊娠结局

差/中等的孕前心血管健康影响SLE女性患者早产和SGA婴儿的妊娠结局。