Cancer Res:寨卡病毒可杀死癌细胞治愈脑瘤

2018-04-29 梅斯医学 梅斯医学

据英国《每日邮报》4 月 26 日报道,近日,巴西圣保罗大学一组研究人员经过反复试验,发现寨卡病毒可以杀死癌细胞从而治愈脑瘤。这种脑瘤会对五岁以下的儿童造成毁灭性的伤害。

近日,巴西圣保罗大学一组研究人员经过反复试验,发现寨卡病毒可以杀死癌细胞从而治愈恶性脑胚胎母细胞瘤。这种脑瘤会对五岁以下的儿童造成毁灭性的伤害。不过,目前仍然是动物实验的结果。

研究人员表示,为了确定寨卡病毒对抗癌细胞是否有效,他们将该病毒感染这种脑瘤细胞,结果表明,寨卡病毒杀死了棘手的癌细胞,对周围健康的神经元没有明显影响。这项新研究的结果因此表明,能使儿童致命的病毒也可以挽救一些癌症患者的生命。圣保罗大学的研究人员已经计划对儿童进行试验。

寨卡病毒是由蚊子传播的病毒。如果被感染病毒的蚊子叮咬,孕妇肚子里的婴儿很容易患上小头畸形症,对于大多数成年人来说,症状一般很少会出现,但这种病毒会对子宫内的婴儿构成严重威胁,从而导致婴儿出生时头部异常小,大脑发育不全,这种情况被称为小头畸形。尽管目前寨卡病毒已不再是“国际医疗紧急事件”,但世卫组织表示对其仍旧不能掉以轻心。

对于这一发现,专家表示,如果能确定寨卡病毒对治疗脑癌患者是安全的,这无疑会造福无数脑癌患者,为此他们将继续努力,早日攻破这一难题。

研究人员也在实验中尝试用寨卡病毒杀死前列腺癌、肠癌和乳腺癌的癌细胞,不过几乎没有效果。

原始出处:

Kaid C, Goulart E, Caires-Júnior LC, Araujo BHS, Soares-Schanoski A, Siqueira Bueno HM, Silva KAT, Astray RM, Assoni AF, Ribeiro Júnior AF, Ventini DC, Puglia ALP, Gomes RP, Zatz M, Okamoto OK. Zika virus selectively kills aggressive human embryonal CNS tumor cells in vitro and in vivo. Cancer Res. 2018 Apr 26. pii: canres.3201.2017. doi: 10.1158/0008-5472

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    2018-05-13 1771ae4158m

    学习一下很不错

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    2018-05-02 半夏微凉

    学习了谢谢分享

    0

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  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:04:10 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310337, encodeId=013931033e0c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:04:01 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310335, encodeId=d452310335aa, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:03:50 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-30 jxrzshh
  6. 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level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:03:50 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-30 yxch36
  7. 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level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:03:50 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 明月清辉

    谢谢分享.学习了

    0

  8. 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level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:03:50 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 Y—xianghai

    学习了长知识

    0

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level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Apr 29 08:03:50 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 Y—xianghai

    学习了长知识

    0

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    2018-04-29 Y—xianghai

    学习了长知识

    0

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Science:双重磅实锤来了!美奥两国团队分别独立证实,转移到淋巴结的癌细胞可以再次产生远处转移灶

即使同是癌症病房,也会有悲喜两重天,而患者和家属最怕从医生口中听到的,大概就是“转移”两个字吧。中年男人当场晕倒在地,新婚小夫妇互相抱头痛哭,这样的场景可不是影视剧里的杜撰。而如果转移前面多了“淋巴结”三个字,医生和患者大概都会长舒一口气:还好没有远处转移,有根治的机会。

Sci Rep:人类前列腺正常细胞和癌细胞外代谢组学区分

血清前列腺特异性抗原(PSA)是目前最常用于前列腺癌(PCa)检测临床实践的生物标记。然而,该生物标记具有一些缺陷。最近,有研究人员基于无靶标气相色谱-质谱分析法(GC-MS)对PCa细胞的代谢组进行了分析,从而来验证在PCa细胞系中,与正常前列腺细胞相比,代谢情况发生变化。研究人员利用GC-MS技术,评估了4个前列腺细胞系和1个正常前列腺细胞系细胞外基质(外代谢组)的挥发性有机化合物差异(VOC

Cell & Science:癌细胞如何抵抗化疗? 这两篇结构研究或许可以解释

为了杀死癌细胞,化疗药物必须首先进入它们体内。但癌细胞非常精明,有些癌细胞甚至在药物开始发挥效果之前使用分子泵排出药物。最近,由洛克菲勒大学膜生物学和生物物理学实验室负责人、霍华德休斯医学研究所研究员陈觉(Jue Chen)教授领导的新研究揭示了细胞“吐出”药物的过程,或许有助于设计更有效的化疗方法。

Dev Cell:关闭细胞自噬作用或能帮助化疗等疗法有效杀灭癌细胞

一种名为细胞自噬(autophagy)的过程能够帮助细胞在压力下存活,其能够扮演细胞中的再循环系统来帮助降解并再利用细胞中的废物,从而促进细胞健康存活;但不幸的是,癌细胞通常会拦截细胞自噬来躲避抗癌药物对癌细胞的杀灭作用,这就使得细胞自噬成为了科学家们开发新型抗癌疗法的潜在靶点,阻断自噬就能够使得癌细胞无法克服疗法造成的压力,从而诱发癌细胞死亡;实际上,目前很多临床试验都正在检测自噬抑制剂联合化疗

LPS:胰腺癌迎来全新突破,双热消融全面清除癌细胞

据宾厄姆顿大学的新研究,加热和冷冻的过程称为双热消融可以杀死胰腺癌细胞。