JCEM:代谢健康和肥胖状况对痴呆风险的影响

2019-03-01 xing.T 网络

由此可见,晚年MHO表型可使整体痴呆和AD的风险降低,但VaD则不然。有必要对其他人群进行进一步的研究,以便更好地了解当前的结果,并预测最容易患痴呆症的个体。

具有正常代谢特征的肥胖受试者,即所谓的代谢健康肥胖(MHO)者的痴呆风险仍未明确。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在确定晚期代谢健康与肥胖状态和痴呆事件风险之间的关系。

该研究为回顾性队列研究,以韩国国民健康保险系统为基础,纳入了2009年到2012年期间接受健康检查的12296863名50岁以上基线没有痴呆症的成年人。主要结局指标为总体痴呆、阿尔茨海默病(AD)和血管性痴呆(VaD)的发生情况。

在年龄≥60岁的人群中,363932名受试者(6.4%)在中位随访65个月期间发生痴呆(四分位距[IQR]为51-74个月)。相比于代谢健康的非肥胖(MHNO)者,MHO者总体痴呆(风险比[HR]为0.85,95%置信区间[CI]为0.84-0.86)和AD(HR为0.87,95%CI为0.86-0.88)发生率最低,但VaD则不然。除肥胖外,代谢综合征的所有组分都显著提高了痴呆的风险,这些相关性在VaD患者中更为明显。特别是,体重不足会大大增加痴呆症的风险。

由此可见,晚年MHO表型可使整体痴呆和AD的风险降低,但VaD则不然。有必要对其他人群进行进一步的研究,以便更好地了解当前的结果,并预测最容易患痴呆症的个体。

原始出处:

Ji-Yeon Lee.et al.Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late-life: a Population-based Cohort Study.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2018-01491

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    2020-01-08 achengzhao
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    2019-07-01 smallant2015
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    2019-03-01 junJUN

    老年人痴呆何药可用??

    0

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