Hypertension:短期高浓度PM2.5暴露对中心动脉血压的影响

2019-11-17 QQY MedSci原创

与外周血压相比,中心主动脉血压(BP)与心血管风险的关系越来越密切。但颗粒物污染对主动脉中心血压的影响尚未得到明确证实。本研究在中国人群中评估环境细颗粒物(直径≤2.5μm,PM2.5)短期暴露与主动脉血压的关系。在最终分析中,共有4715次访问,包括起始的2151次访问和随访过程中的2564次访问。采用Omron HEM-9000AI机无创测量中心动脉收缩压(cSBP)。根据空气污染监测站的数据

与外周血压相比,中心主动脉血压(BP)与心血管风险的关系越来越密切。但颗粒物污染对主动脉中心血压的影响尚未得到明确证实。

本研究在中国人群中评估环境细颗粒物(直径≤2.5μm,PM2.5)短期暴露与主动脉血压的关系。

在最终分析中,共有4715次访问,包括起始的2151次访问和随访过程中的2564次访问。采用Omron HEM-9000AI机无创测量中心动脉收缩压(cSBP)。根据空气污染监测站的数据来估计每天的PM2.5接触量。



PM2.5暴露和cSBP之间的关系呈非线性的,PM2.5暴露浓度>100 μg/cm3时,cSBP显著升高。测量cSBP这一天的日常PM2.5浓度增加一个四分位(80.25 μg/cm3)时,cSBP升高2.54 mmHg(95% CI 0.92-4.16)。除心血管疾病外,PM2.5与cSBP的相关性不受年龄、性别、体重指数、药物和其他共病的影响。

本研究结果表明,短期暴露于高浓度的环境PM2.5(>100μg /cm3)可显著升高中心主动脉BP。

原始出处:

Fangfang Fan, et al.Acute Effects of High-Level PM2.5 Exposure on Central Blood Pressure.Hypertension. 2019;74:1349–1356

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    2020-06-09 feather89
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