BMJ: 50岁时心血管健康水平与痴呆发病率的关联

2019-08-14 不详 MedSci原创

本项研究旨在探究50岁时简单生活心血管健康7项评分与痴呆发病率之间的关系。

背景及目的:
本项研究旨在探究50岁时简单生活心血管健康7项评分与痴呆发病率之间的关系。

方法:
本项研究是一项前瞻性队列研究。从英国伦敦招募了7899名参与者,所有人均有50岁时心血管健康评分的数据。心血管健康评分包括四种行为(吸烟,饮食,体力活动,体重指数)和三种实验室指标(空腹血糖,血胆固醇,血压)指标,以三点量表(0,1,2)编码。心血管健康评分是七个指标的总和(评分范围0-14),并且被分类为差(评分0-6),中等(7-11)和最佳(12-14)心血管健康。主要观察结局是通过与医院,精神卫生服务和死亡登记的联系确定痴呆症的发作。

结果:
在中位随访24.7年的时间里记录了347例痴呆事件。与心血管健康状况不佳的每***年痴呆发病率3.2(95%可信区间2.5~4.0)相比,每1000人年的绝对差异率为-1.5(95%CI:-2.3 - 0.7)。较高的心血管健康评分与较低的痴呆风险相关(心血管健康评分中每1分增加的风险比为0.89(0.85至0.95))。对于行为和生物分量表观察到与痴呆的类似关联(分数中的每1点增量的风险比分别为0.87(0.81至0.93)和0.91(0.83至1.00))。

结论
简单生活心血管健康7项评分较为优异的中年人晚年痴呆症的风险明显降低。

原始出处:

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    2020-02-17 gaoxiaoe
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    2019-08-15 junJUN

    老年人痴呆何药可用??

    0

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    2019-08-14 天地飞扬

    学习

    0

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