关键Y染色体基因功能丧失会增加男性患癌风险

2020-01-20 Allan MedSci原创

许多研究表明,男性比女性更容易患癌症,但科学界对这种差异的原因仍知之甚少。巴塞罗那全球健康研究所(ISGlobal)的研究人员进行了一项研究,发现了导致男性罹患癌症风险更高的关键生物学机制:某些Y染色体性别基因的功能丧失。

许多研究表明,男性比女性更容易患癌症,但科学界对这种差异的原因仍知之甚少。巴塞罗那全球健康研究所(ISGlobal)的研究人员进行了一项研究,发现了导致男性罹患癌症风险更高的关键生物学机制:某些Y染色体性别基因的功能丧失。研究人员利用来自9,000例患者的数据,研究了各种癌症患者的Y染色体基因功能。研究结果表明,癌症风险随着关键Y染色体基因功能的丧失而增加。

Y染色体是属于XY性别决定系统的大多数哺乳动物(包括人类)的两条性染色体之一。在哺乳动物的Y染色体中含有的SRY基因能触发睾丸的生长,并由此决定雄性性状。人类的Y染色体中包含约6千万个碱基对。


原始出处:

https://www.firstwordpharma.com/node/1694585?tsid=28®ion_id=4

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2023-09-02 侠胆医心 来自上海

    关键#Y染色体#基因功能丧失会增加男性患癌风险#癌症#

    0

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-23 125077a8m60暂无昵称

    好的

    0

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-23 thm112988

    0

  5. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
  6. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
  7. 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00:07:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601463, encodeId=4baf160146352, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Wed Jan 22 00:07:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378382, encodeId=2bdb3e8382b1, content=看来少了一条腿就是不行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue Jan 21 22:02:58 CST 2020, time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-22 周虎
  8. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-22 lq0307
  9. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-21 njwbhuang

    看来少了一条腿就是不行啊

    0

  10. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-20 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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