Nat Commun：研究发现LL-37/CRAMP是血小板活化和血栓炎症的重要介质

2018-05-02 MedSci MedSci原创

白细胞释放的抗菌肽有助于消除病原体和激活免疫系统，但是其在血栓形成中的作用尚未完全了解。在这里我们显示cathelicidin LL-37在急性心肌梗塞患者的血栓中的水平较高。其小鼠同系物CRAMP存在于血管损伤后的小鼠动脉血栓中，并且主要来源于循环中性粒细胞。骨髓嵌合体小鼠中造血CRAMP的缺乏减少了血小板募集和血栓形成。LL-37和CRAMP通过蛋白酪氨酸激酶Src/Syk和磷脂酶C参与糖蛋白

白细胞释放的抗菌肽有助于消除病原体和激活免疫系统，但是其在血栓形成中的作用尚未完全了解。

在这里我们显示cathelicidin LL-37在急性心肌梗塞患者的血栓中的水平较高。其小鼠同系物CRAMP存在于血管损伤后的小鼠动脉血栓中，并且主要来源于循环中性粒细胞。骨髓嵌合体小鼠中造血CRAMP的缺乏减少了血小板募集和血栓形成。

LL-37和CRAMP通过蛋白酪氨酸激酶Src/Syk和磷脂酶C参与糖蛋白VI受体和下游信号传导，从而在体外诱导血小板活化。除了急性血栓形成之外，LL-37/CRAMP依赖性血小板活化通过调节嗜中性粒细胞的募集和外渗到组织中来促进血小板-中性粒细胞在其他炎症条件下的相互作用。

缺乏CRAMP可以消除酸性肺损伤，这是一种依赖于血小板-中性粒细胞相互作用的小鼠肺炎模型。我们建议LL-37/CRAMP代表血小板活化和血栓炎症的重要介质。

原始出处：

Joachim Pircher, Thomas Czermak, et al. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun. 2018; 9: 1523. doi: 10.1038/s41467-018-03925-2

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2019-02-17 hanhaisha2020

#研究发现#

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2018-05-05 liye789132251

#Nat#

31 0
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2018-08-29 liuli5079

#COMMUN#

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2018-05-05 yfjms

学习

66 0
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2018-05-02 惠映实验室

学习了.谢谢分享.

74 0
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2018-05-02 虈亣靌

学习了.谢谢作者分享!

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